摘要
为探讨2型糖尿病患者瞬目反射(BR)的改变及其影响因素,用肌电图仪测定85例2型糖尿病患者左右两侧的R1、R2、R2’波的潜伏期、波幅,将其均值分别与正常值做对比;并将病人分为BR阳性组与阴性组进行分析。发现2型糖尿病患者左右两侧R1、R2、R2’各反应波潜伏期均值与正常值相比均有不同程度的延长,有显著差异(P<0.001)。BR阳性组与阴性组的年龄和病程均存在显著差异(P<0.05和P<0.01)。且病程越长,BR各值的变化越明显,两者间存在一定相关性。由此可见2型糖尿病可对患者造成一定程度的中枢神经系统损害,影响脑干功能。2型糖尿病的病程与BR的潜伏期变化程度存在一定相关性。不同病程的病人其BR异常率不同,随病人病程的延长BR异常率也逐渐增高。结果提示:BR可为2型糖尿病合并中枢神经系统损害提供客观而灵敏的指标。
The objective was to explore the change of blink reflex (BR) in patients with type 2 diabetes mellitus and its relationship with other correlated factors. The latencies and amplitudes of waves of bilateral R1, R2 and R2' in BR were detected in 85 patients, whose average were contrasted with normal value. The patients were divided into two groups, the BR-positive group and the BR-negative group. The latencies and amplitudes of waves of bilateral R1, R2 and R2' in patients with type 2 diabetes mellitus were somewhat longer than the normal. The difference was significant in statistics(P<0.05). Also significant differences of ages and disease courses were found between the BR-positive group and the BR-negative group. The longer diabetes course lasted, the more notably each value of BR changed. They had some correlation. Type 2 diabetes mellitus could cause some impairments of the central nervous system and affect the function of brainstem. Patients' ages and disease course had certain correlation with the latencies and amplitudes of waves of BR. Different patients had different proportion of abnormality in BR. With the extension of course of diabetes, abnormal ratio increased. So BR might provide an objective and sensitive index for the asymptomatic impairment of the central nervous system caused by diabetes.
出处
《首都医科大学学报》
CAS
2003年第2期187-189,共3页
Journal of Capital Medical University
