摘要
目的 :研究丹参素胶囊对大鼠血小板聚集性和血液流变学及血栓形成的影响。方法 :以ADP为诱导剂 ,观察其对体外血小板聚集率的作用 ;采用电刺激法 ,测定闭塞性血栓形成的时间 ;用冰水刺激制备“血瘀”模型 ,检测主要流变学指标。结果 :丹参素胶囊能明显抑制由ADP诱导的大鼠血小板体外聚集活性 ,延长电刺激大鼠颈总动脉后血栓形成时间 ,降低“血瘀”大鼠全血粘度、血浆粘度、红细胞压积、红细胞电泳时间、卡松屈服应力以及红细胞聚集指数 ,改善机体血液流变性。结论 :丹参素胶囊能明显降低血液“浓、粘、聚、凝”状态 ,具有良好的活血化瘀作用。
Objective: To investigate the effect of Danshensu Capsules on platelet aggregation, experimental thrombosis and hemorrheology in rat. Methods : The effects of Danshensu Capsules were observed on platelet aggregation induced by ADP. Occlusive thrombotic time was determined by electrostimulating; “blood stasis” model was prepared by ice water stimulation and the main hemorheological indexes were detected. Results : Danshensu Capsules could greatly inhibit the platelet aggregation in rat induced by ADP and delay occlusive thrombosis time after electrostimulating rat common carotid artery as well as decrease whole blood viscosity, plasma viscosity, red-cell specific volume, red-cell electrophoresis time, yield stress and red-cell aggregation indexes in experimental rat with the blood stasis syndrone. The rat's hemorheological properties were improved. Conclusion : Danshensu Capsules could decrease obviously the blood state with “dense、viscosity、aggregation、coagulation” and have obvious actions of blood-activating and stasis-eliminating.
出处
《中成药》
CAS
CSCD
北大核心
2003年第8期637-639,共3页
Chinese Traditional Patent Medicine
