摘要
观察了去纤酶溶栓治疗急性心肌梗塞的效果和副作用。与常规治疗组比较,去纤酶溶栓可使梗塞相关动脉再通,肌酸磷酸激酶(CPK)高峰时间提前,差异显著;左室射血分数趋于改善,梗塞并发症和死亡率有降低趋势,但差异无统计学意义。去纤酶的副作用主要为出血和过敏反应,但均不严重。
To investigate the thrombolytic effects of defibrace, 78 patients were on a trial therapy with defibrase against 70 patients on conventional therapy. Defibrase, 0.075U/kg in 100 to 200ml of normal saline was infused intravenously or in the coronary over a period of 60-90 min. Coronary ateriography was performed in some of the patients. Plasma CPK was measured serially since the onset of chest pain. LVEF by both 2D echocardiography and radionuclide ventriculography were performed 2 weeks after the treatment. Of 6 patients with total occlusion of the infarct-related artery (IRA), intracoronary defibrase resulted in recanalization in 2 while intravenous defibrase resulted re-canalization in 1. Of the 7 patients who underwent coronary arteriography 90 min after the intravenous defibrase, patent IRA was demonstrated in 5. Of the 16 patients undergoing coronary arteriography 2 weeks after intravenous defibrase, patent IRA was demonstrated in 13. In contrast, only 11 of 26 patients in the conventional group who had coronary arteriography 2 weeks after admission showed patent IRA. In comparision to the conventional therapy, the defibrase thrombolysis produced a more significant early peaking of CPK. The LVEF as determined by echocardiography was significantly higher in defibrase than in the conventional group. The LVEF determined by radionuclide ventriculography was slightly higher in defibrase than in the conventional group, but the difference was statistically insignificant. Infarction complication and mortality was higher in conventional group than in the defibrase group, with difference also insignificant. No serious spontaneous bleeding occured after defibrase thrombolysis. Significant bleedings were related to yearly catheterization after defibrase thrombolysis.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
1992年第6期405-408,共4页
Medical Journal of Chinese People's Liberation Army
关键词
去纤酶
溶栓疗法
心肌梗塞
Defibrase
Thrombolysis
Acute myocardial infarction
