摘要
目的探讨凝血系统在老年人不稳定型心绞痛（ＵＡ）发生和发展中的作用。方法采用一组抗纤维蛋白单克隆抗体（ＳＺ－５８、６４、６５）酶免疫分析法测定２６例老年ＵＡ患者、２４例稳定型心绞痛（ＳＡ）患者和２０例健康老年人（对照组）血浆纤维蛋白原（Ｆｇ）、可溶性纤维蛋白复合物（ＳＦＣ）及血清纤维蛋白降解产物（ＦＤＰ）的浓度。结果ＵＡ患者心绞痛发作时血浆Ｆｇ、ＳＦＣ及血清ＦＤＰ浓度（分别为３．７±０．６ｇ／Ｌ、４９．６±１９．３ｍｇ／Ｌ、３２５．６±７９．４μｇ／Ｌ）显著高于ＳＡ患者心绞痛发作时（分别为３．２±０．６ｇ／Ｌ、２０．９±１０．４ｍｇ／Ｌ、２２４．４±４７．４μｇ／Ｌ）和健康对照组（均为Ｐ＜０．０１），后两者间差异无显著性。ＵＡ发作终止后血浆Ｆｇ和血清ＦＤＰ浓度高于健康对照组，但差异无显著性。结论血栓形成是老年人ＵＡ发生和发展的重要因素之一。
Objective To study the role of coagulation system in the development of unstable angina (UA) in elderly. Methods A group of monoclonal antibodies of antifibrin (SZ58,64,65) was adopted to measure plasma fibrinogen (Fg), soluble fibrin complex (SFC) and serum fibrin degradation products (FDP) in 26 elderly patients with UA, 24 patients with stable angina (SA) and 20 elderly healthy controls by enzyme immunoassay. Results The values of plasma Fg, SFC and serum FDP in the episode of elderly patients with UA were markedly higher than those in the episode of SA patients and those in controls (both P<001), but there was no significant differences between the latter two groups (P>005). Plasma Fg and serum FDP in UA patients 30 minutes after relief of angina were slightly higher than those of controls but of no statistical significance (P>005). Conclusions The results suggest that thrombosis might play an important role in the pathogenesis and progress of UA in elderly patients.
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
1998年第1期12-14,共3页
Chinese Journal of Geriatrics
关键词
不稳定型心绞痛
纤维蛋白原
纤维蛋白
老年人
Angina
unstable\ \ Fibrinogen\ \ Fibrin fibrinogen degradation products
