摘要
测定了226名健康妇女桡骨骨密度、血清5种性激素及与骨代谢有关的部分生化指标。结果显示,更年期后血清雌二醇、泌乳素浓度显著降低,卵泡刺激素、黄体生成素、血清碱性磷酸酶升高,尿钙、磷、羟脯氨酸排出量增多,桡骨骨密度持续减低,骨年丢失率绝经后2年内大于6％,11年后小于2％。骨密度减低及血、尿生化指标的变化与雌二醇的减低密切相关,提示绝经后雌激素的减少可能是导致骨质疏松的重要原因。
An investigation was carried out in 226 healthy women by measuring their radius bone density (RBD), five serum sex hormones and some biochemical indices relevant to bone metabolism. The results showed that there were significant decrease of estradiol and prolactin, elevation of follicular stimulating hormone, lutinizing hormone and serum alkaline phosphorase, and increased elimination of calcium, phosphorus and hydroxyproline after menopaucek In addition, there occured a continuous decline of RBD, with the highest annual rate (greater than 6%) within 2 years and the lowest (less than 2%) after 11 years posstmenopause. The close correlation of estra, diol concentration to changes in RBD and biochemical indices suggests that postmenopausal estrogen deficiency may be one of the important factors in the development of osteoporosis.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
1992年第3期180-183,共4页
Medical Journal of Chinese People's Liberation Army
关键词
绝经
骨质疏松
雌激素
Menopause
Osteoporosis
Estrogen
