摘要
检测了男性肝炎后肝硬变53例患者(观察组)和20名健康男性(对照组)血浆睾酮(T)、雌二醇(E_2)、催乳素(PRL)和血管活性肠肽(VIP)的含量。结果:观察组T显著降低,PRL和VIP明显升高,E_2正常。4种激素含量改变与乳腺增生和蜘蛛痣的出现均无相关性。提示这些病征的出现,可能还有其他尚来揭示的机制参与。
The mechanism of feminization which is frequently observed in men with cirrhosis of the liver, has not been satisfactorily explained. We have measured plasma immunoreactive testosterone (T), estradiol (E2), prolactin (PRL) and vasoactive intestinal peptide (VIP) in 53 men with post-hepatitic cirrhosis in order to further elucidate the possible hormonal mechanisms responsible for the observed feminization. The results compared with that of 20 healthy men of similar ages showed that low levels of T, elevated concentrations of PRL and VIP and normal values of E2 were seen in cirrhosis. No relationship existed between the levels of T, E2, PRL, VIP or E2/ T ratio and the presence of gynecomastia or spider angioma. It is probable that other undiscovered mechanisms are involved in the pathogenesis of feminization.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
1992年第1期26-28,共3页
Medical Journal of Chinese People's Liberation Army
关键词
肝硬变
男性
性激素
睾丸酮
雌二醇
Testosterone
Estradiol
Prolactin
Vasoactive intestinal peptide
Post-hepatitic cirrhosis
