摘要
目的 研究内源性高甘油三酯血症患者凝血及纤溶活性的改变及其与血脂及载脂蛋白的相关性。方法 测定内源性高甘油三酯血症 ( HTG)患者及正常对照者凝血酶原时间 ( PT)、活化部分凝血酶原时间 ( APTT)、组织型纤溶酶原活化物活性 ( t- PA)以及纤溶酶原活化物抑制物 - 1活性 ( PAI- 1)、血浆纤维蛋白原 ( Fg)含量和血清脂质及载脂蛋白含量。结果 HTG患者 PT和 APTT较对照组显著缩短 ( P<0 .0 1,P<0 .0 5 ) ,Fg含量及 PAI-1活性显著增强 ( P<0 .0 1) ,t- PA活性无明显差异。 PT与 HDL - C水平呈显著正相关 ( r=0 .44 5 ,P<0 .0 1) ,与TG、apo C 、BG含量及 BMI呈负相关 ( r=- 0 .2 94,- 0 .3 2 0 ,- 0 .2 82 ,- 0 .2 72 ,P<0 .0 5 ) ,APTT与 TG及apo C 含量呈负相关 ( r=- 0 .3 45 ,- 0 .3 2 0 ,P<0 .0 5 )。 t- PA活性与 BG浓度呈显著负相关 ( r=- 0 .3 3 6,P<0 .0 1)。 PAI- 1活性及 Fg含量与 TG、apo C 、C 及 E含量呈正相关 ( r=0 .40 0 ,0 .40 8,0 .497,0 .45 4,P<0 .0 1及 r=0 .64 2 ,0 .5 81,0 .673 ,0 .3 0 4,P<0 .0 1) ,与 HDL - C水平呈负相关 ( r=- 0 .3 66,- 0 .5 2 4,P<0 .0 1)。
Objective To investigate the changes of plasma haemostatic and fibrinolytic activities and their relationship to serum lipids and apolipoproteins levels in endogenous hypertriglyceridemic patients. Methods We determined the plasma prothrombin time(PT), activated partial thromplastin time(APTT), activity of tissue-type plasminogen activator(t-PA), activity of plasminogen activator inhibitor-1 (PAI-1) and fibrinogen(Fg) level of 24 endogenous hyper-triglyceridemic patients and 34 healthy controls, and observed their relationship to serum lipids and apolipoproteins. Results The PT and APTT of patients with hypertriglyceridemia were obviously shorter than those of control subjects (P<0.01, P<0.05); PAI-1 of patients was significant higher than that of control group (P<0.01); there was no statistically significant difference in t-PAI-1:a between the control subjects and the hypertriglyceridemic patients; the levels of Fg in patients was 27% higher than that in healthy control (P<0 01). The correlation analysis indicated that PT was significantly associated with the levels of plasma HDL-C (r=0.445, P<0.01), and inversely associated with the levels of plasma TG, apoCⅢ,BG and BMI (r=-0.294, -0 320,-0.282,-0.272, P<0.05); APTT was negatively correlated with serum TG and apoCⅢ levels (r= -0 345,-0 320,P<0.05); t-PA was negatively correlated with BG levels (r= -0.336, P< 0.01). PAI-1 and Fg levels were strongly correlated with serum TG, apoCⅡ,CⅢ and E levels (r=0.400, 0.408, 0.497, 0.454, P<0 01 and r=0.642, 0.581, 0.673, 0.304, P<0.01, respectively), and negatively correlated with HDL-C (r= -0 366, -0.524, P<0.01). Conclusion Increasing of coagulating activity and decreasing of fibrinolytic activity in hypertriglyceridemic patients were significantly associated with serum lipids and apolipoproteins levels.
出处
《四川大学学报（医学版）》
CAS
CSCD
北大核心
2003年第3期405-408,共4页
Journal of Sichuan University(Medical Sciences)
基金
国家重点基础研究发展规划 (编号 TG2 0 0 0 0 5 6910 )资助
关键词
内源性高甘油三酯血症
凝血
纤溶活性
血脂
载脂蛋白
Blood lipids Hypertriglyceridemia Coagulating activity Fibrinolytic activity Apolipoproteins Blood glucose
