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5-脂氧合酶及其基因表达调控的研究进展 被引量:5

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摘要 5-脂氧合酶是白三烯类代谢产物生成的关键酶,其酶活性及基因表达与炎性疾病、老年性痴呆和肿瘤等疾病的发生发展有密切的关系。本文主要对5-脂氧合酶的活性及其表达调控的研究现状进行综述。
出处 《国外医学(临床生物化学与检验学分册)》 2003年第4期225-226,232,共3页 Foreign Medical Sciences(section of Clinical Biochemistry and Laboratory Medicine
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  • 1Werz O,Burkert E,Samuelsson B, et al. Activation of 5-lipoxygenase by cell stress is calcium independent in human polymorphonuclear leukocytes [J]. Blood, 2002, 99(3): 1044-1052.
  • 2Radmark OP. The molecular biology and regulation of 5-lipoxygenase[J]. Am J Respir Crit Care Med, 2000,161:s11-s15.
  • 3Brock TG, Healy AM. Nuclear import of arachidonate 5-lipoxygenase[J]. Arch Immunol Ther Exp, 2000,48(6):481-486.
  • 4Hanaka H, Shimizu T, Izumi T. Nuclear-localization-signal-dependent and uclear-export signal-dependent mechanisms determine the localization of 5-lipoxygenase[J].Biochem J,2002,361(Pt 3) :505-514.
  • 5Chen XS, Funk CD. The N-terminal "beta-barrel" domain of 5-lipoxygenase in essential for nuclear membrane translocation[J]. J Biol Chem, 2001,276(1): 811-818.
  • 6Kulkarni S, Das S, Funk CD, e t al. Molecular basis of the specific subcellular localization of the C2-1ike domain of 5-lipoxygenase[J]. J Biol Chem, 2002, 277(15):13167-13174.
  • 7Werz O,Klemm J, Samuelsson B, et al. Phorbol ester upregulates capacities for nuclear translocation and phosphorylation of 5-lipoxygenase in Mono Mac 6 cells and human polymorphonuclear leukocytes[J]. Blood, 2001,97(8) :2487-2495.
  • 8Werz O, Klemm J, Samuelsson B, et al. 5-lipoxygenase is phosphorylated by p38 kinase-dependent MAPKAP kinase[J]. Proc Natl Acad Sci USA, 2000,97(10): 5261-5266.
  • 9Werz O,Klemm J,Radmark O, et al. p38 MAP kinase mediates stress-induced leukotriene synthesis in a human B-lymphocyte cell line[J]. J Leukoc Biol,2001,70(5):830-838.
  • 10Silverman ES, Le L,Baron RM, et al. Cloning and functional analysis of the mouse 5-lipoxygenase promoter[J].Am J Respir Cell Mol Biol,2002,26(4):475-483.

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