摘要
目的 了解慢性肝炎病人门静脉主干 (MPV)、脾静脉 (SPV)直径、脾脏大小以及周围血细胞计数与肝纤维化程度的关系。方法 对 13 2例慢性肝炎病人做肝组织病理检查 ,按肝纤维化分级分为S1～S4组 ,B超测量MPV与SPV直径 ,以脾指数 (SPI)表示脾脏大小 ,常规方法测量外周血的白细胞数 (WBC)、红细胞数 (RBC)和血小板计数 (PLT) ,比较上述各组病人几种指标的差异。结果 S3组与S4组病人MPV与SPV直径大于S1组 ,S1组MPV和SPV直径分别为 ( 11.86± 1.3 6)mm和 ( 5 .76± 1.3 1)mm ,S4组为 ( 13 .0 6± 1.2 4)mm和 ( 8.0± 1.8)mm ,SPI从S1组 ( 17.5 7± 6.2 3 )cm2 升高到S4组的 ( 2 8.96± 11.62 )cm2 。从S1组到S4组 ,RBC、WBC和PLT逐渐减低 ,S1组分别为 ( 4.64± 0 .63 )× 10 12 /L ,( 4.1± 1.1)×10 9/L和 ( 89.2 3± 3 5 .71)× 10 9/L。其中 ,S3与S4组三项指标都显著低于S1组。结论 随着肝组织纤维化程度逐渐加重 ,慢性肝炎病人门静脉主干、脾静脉直径逐渐扩张 ,脾脏逐渐增大 ,外周血WBC。
Objective To study the relationship between liver fibrosis stages and diameters of main portal vein (MPV) and spleen vein (SPV),spleen indexes(SPI) and peripheral blood cell counts. Methods 132 patients with chronic viral hepatitis were divided into 4 groups according to liver fibrosis stages. The RBC, WBC and PLT counts were tested routinely. The MPV and SPV diameters and the sizes of spleen (SPI) were measured by ulrasonography. Results 1) The MPV and SPV diameters and SPI were, respectively,(11.86±1.36)mm.(5.76±131)mm and (17.57±6.23)cm 2 in group S1;(12.24±1.21)mm,(6.28±1.31)mm and (17.29±6.93)cm 2 in group S2;(12.41±1.24)mm,(7.05±1.56)mm and (22.04±8.29)cm 2 in group S3;(13.06±1.24)mm,(8.0±1.8)mm and (28.96±11.62)cm 2 in group S4. Significant differences of the MPV and SPV diameters and SPI were found between group S4 and group S1 (P<0.05), group S4 and group S2 (P<0.05).The SPV diameter in group S3 was significantly higher than that in group S1 (P<0.05). 2) The peripheral blood cell counts decreased gradually from group S1 to group S4. The RBC WBC and PLT counts in group S1 were (4.64±0.63) ×10 12/L, (5.45±1.62)×10 9/L and (174.52±57.06)×10 9/l,and these in group s4 were (4.01±0.76)×10 12/L,(4.1±1.1)×10 9/L and (89.23±35.71)×10 9/L, respectively. The differences of the counts of use and PLT were significant between group S4 and S1 (P<0.05), group S3 and group S1(P<0.05). Comparing to the other groups, the RBC count in group S4 was significantly decreased (P<0.05).Conclusions With the progression of liver fibrosis, the MPV and SPV diameters and SPI increase, and the peripheral blood cell counts decreased gradually in patients with chronic viral hepatitis.
出处
《齐齐哈尔医学院学报》
2003年第5期486-487,共2页
Journal of Qiqihar Medical University
