摘要
目的 探讨联合检测血清肿瘤标记物CA12 5、癌胚抗原 (CEA)、甲胎蛋白 (AFP)对鉴别附件肿块良恶性的价值。方法 130例附件肿块患者 ,术前测定血清肿瘤标记物CA12 5 ,CEA ,AFP ,术后病理检查组织学分型 ,结果进行比较。结果 良恶性附件肿块间CA12 5 ,CEA ,AFP水平相比均有显著性差异 ,以CA12 5≥ 35× 10 3 U/L ,CEA≥ 5 μg/L ,AFP≥10 μg/L判断为恶性 ,敏感性分别是 6 5 .9% ,2 9.5 % ,2 5 .0 % ;特异性分别是 86 .0 % ,98.8% ,98.8% ;准确性分别是 79.2 % ,75 .4 % ,73.8% ;三者联合检测敏感性为 84 .1%、特异性为83.7%、准确性为 83.8%。结论 肿瘤标记物CA12 5 ,CEA ,AFP联合检测是鉴别附件肿块良恶性。
Objective It is to evaluate of the combained assays of serum tumor markers, CA125, CEA and AFP, for differentiating malignant adnexal masses from benign adnexal masses. Methods The serum levels of CA125, CEA, AFP in 130 patients with adnexal masses were detected before operation. After operation, they were differentiated by histopathology. The results were compared. Results The differences in levels of serum CA125, CEA, AFP between benign and malignant adnexal masses were significant. If the tumor marker cut-off levels were 35×10 3?U/L, 10?μg/L, and 5?μg/L for CA125, CEA and AFP, the sensitivity were 65.9%, 29.5% and 25.0%, the specificity were 86.0%, 98.8% and 98.8%, the accuracy were 79.2%, 75.4% and 73.8% respectively. If all the results of CA125, CEA and AFP were put together, the sensitivity, specificity and accuracy were 84.1%, 83.7% and 83.8% respectively. Conclusion Combained assays of serum tumor markers, CA125, CEA and AFP, is one of the effective methods for differentiating malignant adnexal masses from benign adnexal masses and diagnosis of ovarian cancer in early term.
出处
《现代中西医结合杂志》
CAS
2003年第15期1571-1573,共3页
Modern Journal of Integrated Traditional Chinese and Western Medicine
基金
浙江省卫生厅科研课题 (2 0 0 0B0 4 3)
关键词
肿瘤标记物
诊断
附件肿块
卵巢癌
tumor marker
diagnose
adnexal masses
ovarian cancer
