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EGFRmAb抑制口腔鳞癌细胞增殖的研究 被引量：6

Inhibiting Effect of EGFR Monoclonal Antibody on Proliferation of Oral Squamous Cell Carcinoma
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摘要 目的研究表皮生长因子受体单克隆抗体(EGFRmAb)对口腔鳞癌细胞增殖的抑制作用及其作用机理。方法对Tca8113舌鳞癌细胞系给予不同浓度的EGFRmAb处理,通过分析细胞生长曲线和克隆形成抑制率,观察EGFRmAb225对舌鳞癌细胞的增殖抑制作用,并通过分析细胞周期再分配及细胞周期相关蛋白p27kip1的表达,探讨其作用机制。结果EGFRmAb可抑制舌鳞癌细胞的增殖和克隆形成,可以导致G1期细胞比例上升和S期细胞比例下降,并使p27kip1的表达上调。结论EGFRmAb可以抑制舌鳞癌细胞的增殖,其机制与细胞的G1期阻滞有关。 Objective To investigate the inhibiting effect of epidermal growth factor receptor(EGFRmAb)on proliferation of oral squamous cell carcinoma(SCC).Methods Tca8113squamous cell carcinoma cell line was treated with different concentration of EGFRmAb.Cell growth curve,clone inhibition rate,cell cycle redistribution and the expression of p27kip1were analyzed.Results EGFRmAb inhibited proliferation of oral SCC,leaded to elevation of cell proportion of G1phase cell,decreased the proportion of S phase cell and upregulated the express of p27kip1.Conclusion EGFRmAb inhibited the proliferation of oral SCC,which related with G1phase arrest of tumor cell.
作者 王明国 王中和 胡海生
机构地区 上海第二医科大学附属第九人民医院
出处 《上海口腔医学》 CAS CSCD 2003年第3期200-202,共3页 Shanghai Journal of Stomatology
关键词 表皮生长因子 单克隆抗体 增殖 鳞状细胞癌 Epidermal Growth Factor Monoclonal Antibody Proliferation Squamous Cell Carcinoma
分类号 R739.8 [医药卫生—肿瘤]
  • 相关文献

参考文献5

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共引文献27

同被引文献71

  • 1王中和,RR米列奥,NJ卡西西.头颈部鳞癌术前放疗还是术后放疗——208例临床分析[J].中华放射肿瘤学杂志,1991,0(3):15-18. 被引量：3
  • 2叶金海,邢树忠,吴煜农,周健,龚西騟,张陈平.口腔鳞状细胞癌上皮型钙依赖黏附蛋白及基质金属蛋白酶-2表达的意义[J].口腔医学,2004,24(6):331-333. 被引量：5
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引证文献6

二级引证文献21

上海口腔医学
2003年 第3期

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