摘要
目的 :本文旨在探讨载脂蛋白E血浆水平和基因多态性与胰岛素抵抗关系。方法 :我们进行了大样本北京自然人群横断面研究 ,应用聚合酶链反应 限制性片段长度多态性技术 (PCR RFLP)进行apoE基因分型 ,比较不同基因型人群载脂蛋白E血浆水平 ;分析不同apoE血浆水平和基因型与HOMA IR、胰岛素水平、IRS患病率、IRS中各异常组分患病率的关系。结果 :1 ε2 2 ,ε2 3,ε2 4基因型者较ε3 3者有较高的apoE血浆水平 ;2 高apoE血浆水平IRS患病率增高 ,HOMA IR指数增加 ;3 高apoE血浆水平与高血糖、高血压、脂代谢紊乱和中心型肥胖等IRS各组分均有一定关系 ;4 在高apoE血浆水平下 ,ε2 3基因型对胰岛素抵抗有保护作用 ,而ε3 4者易合并胰岛素抵抗。结论
Objective:The study aims at research the relationship between insulin resistence and apolipoprotein E serum concentration as well as gene polymorphism.Method:We carried out the cross sectional study in general population of Beijing. The study identified apoE genotypes by the technique of PCR RFLP.Result:1.Compared with subjects with ε3/3, those with ε2/2,ε2/3,ε2/4 have higher apoE concentration.2.the higher apoE concentration ,the higher IRS prevalence and HOMA IR. 3.The higher apoE serum concentration have some relation with the components of IRS such as higher glucose, hypertention, lipid disordance, central obesity. 4.ε2/3 genotype protect against insulin resistance, ε3/4 genotype is dispositioned to insulin resistence.Conclusion:The concentration and gene polymorphism of apoE have closely relation with insulin resistence. [
出处
《心肺血管病杂志》
CAS
2003年第2期65-67,共3页
Journal of Cardiovascular and Pulmonary Diseases
