摘要
目的 探讨垂体腺瘤微血管计数 (MVC)与生物学行为的关系。方法 应用免疫组化ABC法对50例侵袭性垂体腺瘤和40例非侵袭性垂体腺瘤组织中第Ⅷ因子相关抗原的表达进行检测 ,并计数肿瘤的微血管。 结果 侵袭性垂体腺瘤的MVC明显高于非侵袭腺瘤 (P<0.01) ;侵袭性腺瘤中复发腺瘤的MVC明显高于非复发腺瘤(P<0.05)。结论 垂体腺瘤的MVC与生物学行为有关 ,有可能作为临床评价肿瘤侵袭性和预后的指标。
Objective To explore the relationship between the tumor microvessel counts(MVC)and biological behavior in pituitary adenomas.Methods The expression of factorⅧrelated antigen were examined in specimens of50invasive pituitary adenomas and40noninvasive adenomas by immunohistochemical ABC method and the positively-stained microvessels were counted.Results The mean MVC in invasive pituitary adenoma was significantly higher than that in noninvasive adenoma(P<0.01).There was also a significant difference of MVC between patients with recurrence and those without recurrence in invasive group(P<0.05).Conclusion The results suggest that MVC is correlated with biological behavior of pituitary adenomas and it may serve as an indicator for tumor invasive potential and clinical prognosis.
出处
《浙江医学》
CAS
2003年第6期331-331,339,共2页
Zhejiang Medical Journal
