摘要
目的 评估CAG方案治疗复发、难治和继发性急性髓细胞白血病 (AML)的疗效。方法 予粒细胞集落刺激因子 (G CSF ,2 0 0 μg·m- 2 ·d- 1 ,第 1～ 14天 ,皮下注射 )、低剂量阿糖胞苷 (Ara C ,10mg·m- 2 ·d- 1 ,第1～ 14天 ,每 12小时皮下注射 )和阿克拉霉素 (Acla,10～ 14mg·m- 2 ·d- 1 ,第 1～ 4天 ,或 6mg·m- 2 ·d- 1 ,第 1～ 8天 ,静脉注射 )在内的CAG方案治疗复发、难治及继发性AML患者 12例。结果 5例患者取得完全缓解 ,4例获部分缓解 ,总有效率达 75 %。可见粒细胞缺乏、血小板减少、继发感染及发热等不良反应。结论 G CSF可促进AML细胞的增殖和分化、增强化疗药物在细胞内的代谢及对白血病细胞的毒性作用 ,是本方案取得较高缓解率而毒副反应较少的理论基础。本方案安全有效。
Objective To evaluate the effect of CAG regimen on acute myeloid leukemia(AML). Methods 12 patients with AML(median age 58, range 29～81) enrolled were treated with CAG regimen consisting of low dose cytosine arabinoside (Ara C, 10 mg·m -2 ·d -1 , q 12 h; day 1～14, subcutaneously), aclarubicin (Acla, 10～14 mg·m -2 ·d -1 ; day 1～ 4; or 6 mg·m -2 ·d -1 ;day 1～8, iv.), and concurrent use of granulocyte colony stimulating factor (G CSF , 200 μg·m -2 ·d -1 , subcutaneously, day 1～14). Results 5 of 12 patients achieved complete remi ssion , and 4 partial remission with a total remission rate of 75%. Myelosuppression presenting as granulocytopenia, complicating infection, and thrombocytopenia were the most significant toxicity in this regimen. Conclusion G CSF enhances the proliferation and differentiation of leukemic cells, and increases the intracellular metabolism of the chemotherapeutic agents and their cytotoxity for leukemic cells. It is a safe and effective regimen.
出处
《上海医学》
CAS
CSCD
北大核心
2003年第6期289-291,共3页
Shanghai Medical Journal
关键词
急性髓细胞白血病
复发性
难治性
继发性
CAG方案
治疗
疗效
Acute myeloid leukemia
Granulocyte colony stimulating factor
Cytosine arabinoside
Aclarubicin
Chemotherapy
Apoptosis
