摘要
目的 :旨在探讨沙棘籽油对大鼠急性缺血性脑梗死的保护作用。方法 :采用大脑中动脉 (MCA)阻断术制作大鼠缺血性脑梗死模型 ,观察药物对脑梗死大鼠脑梗死体积和行为障碍的影响。结果 :沙棘籽油大剂量 (0 .7g·kg-1)和小剂量 (0 .35g·kg-1)均能明显改善MCA阻断大鼠的行为障碍 ,并能减少脑梗死范围。结论 :沙棘籽油对大鼠急性缺血性脑梗死具有明显的保护作用。
Objective: To study the protection of seed oil of Hippophae rhamnoides on ischemic cerebral infarction in rats and the mechanism of the action. Method: Focal cerebral ischemia model was made by middle cerebral artery occlusion(MCAO) in rats. Behavior obstacles of rats were observed. Cerebral infarction volume was determined by Megnetic Resonance Imaging(MRI). Result: Seed oil of Hippophae rhamnides 0.7 and 0.35 g·kg -1 could markedly reduce infarction volume after occlusion of middle cerebral artery in rats and also could ameliorate the behavior obstacles of rats. Conclusion: These results suggested that seed oil of Hippophae rhamnoides had distinct protection to ischemic cerebral infarction in rats.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2003年第6期548-550,共3页
China Journal of Chinese Materia Medica
基金
甘肃省自然科学基金资助项目 (ZR 97 10 1)
关键词
缺血性脑梗死
沙棘籽油
中药
脑梗死体积
行为障碍
seed oil Hippophae rhamnodes
middle cerebral artery occlusion (MCAO)
cerebral infarction
magnetic resonance imaging (MRI)
