摘要
口服给予利脑心0.25和0．5g生药/kg，能明显改善实验性脑梗大鼠的神经症状，使脑梗塞面积显著减小，延长断头后小鼠喘气时间，并能增加其脑内ATP和磷酸肌酸（Pcr）含量，降低其乳酸含量。将1×10－5和1×10－4g／ml浓度的利脑心液进行大鼠脑在位灌流对大鼠血管无明显影响。试验结果表明，利脑心的脑保护作用可能与改变能量代谢有关，而与脑血管阻力无关。
Linaoxin, a herhal preparatlon composed of Salvia miiltiorrhiza, Ligusticum wallichii,Pueraria lobata,and Polygonum multiflorum etc., at doses of O. 25 and o. 5g/kg (ig)significantly improved the neural symptoms of experimental cerehral infarction and reduced the size of infarcted area in rats. At the same doses it also significantly prolonged the hreathing time of mice after decapitation and showed effects on brain energyrnetabolism including the increase of brain ATP and phosphocreatine (Pcr)leveIs and decrease of brain lacticacid (LA)level. Linaoxin suspension at concentrations of l:< 1o s and l X lO-'g/mI for in situ perfusion ofbrain vessels in rats showed little effect on vessel resistance- The above results suggested that the protectiveeffects of Linaoxin on brain might be related to the alteration of brain energy metabolism rather than its asso-ciation with brain vessel resistance.
出处
《中草药》
CAS
CSCD
北大核心
1996年第3期157-160,共4页
Chinese Traditional and Herbal Drugs
