摘要
目的 观察和研究天然青石棉矿物粉尘在动物体内病理变化 ,纤维自身变化、残留特性及表面新生成物质形貌特征。方法 大鼠体内染尘后 ,用高倍显微镜、电子显微镜观察其在动物体内的变化 ,并统计对比纤维变化特征。结果 动物体内机体以吞噬、包裹、缠绕 ,或以生化溶解方式排解粉尘 ,纤维自身则出现变短、尖部圆化、折断、分叉现象 ,也可以出现溶解、迁移、表面化学反应等。在肺泡内的纤维有碳酸盐化的现象。动物体内间皮瘤可生长在注入部位也可在非注入部位。结论 体内纤维粉尘的溶解是一个非常缓慢的过程 ,细小粉尘易于溶解和迁移。纤维在肺内碳酸盐化是体内纤维溶解和反应的新方式。体内粉尘的膜阻滞现象在腹膜、胸膜上较为常见 ,在膜部位不易生成间皮瘤 ,肿瘤多引发在膜的内侧。但膜可以弱纤维化包裹。
Objective To further examine and study the pathogenic change of crocidolite dust, the fiber self-imperceptible changes, remained features and the new surface morphology of crocidolite surface in rat. Methods After the dusts being injected in vivo , the imperceptibility changes in rats were observed and the fiber features were compared with statistics in rat by advanced microscope, SEM analysis. Results The mineral fibrous dusts was shown partly to become asbestos plaque and partly to become naked fiber after being injected into animal. The fibrous surface with asbestos plague grouping might react with some protein to form surace media. The main diseasse caused by mineral fiber would be mesothelioma and fibrous wrap. The tissue would get rid off dusts by licking up, wrapping, twisting or biochemical dissolution. The fiber might become shorten, round on end, broken and branch off or dissolution, movement, and surface reaction etc. The fiber carbonation in alveolus would be a new type of fiber dissolution and reaction in animal. The mesothelioma might grow at infection position or others. Conclusion The dissolution of asbestos fibers in body appeared to be a very slow process and the smaller particles would be easily dissolved and moved. The membrane block would normally exist in peritoneum and pleura, and the few mesothelioma and weak fibrous wrap would be formed in these position.
出处
《中国职业医学》
CAS
北大核心
2003年第3期6-9,共4页
China Occupational Medicine
基金
国家自然科学基金 (40 0 72 0 2 0 )
"教育部优秀青年教师奖"资助项目
关键词
青石棉
粉尘
病变组织
生物溶解
毒性
Crocidolite
Dust
Disease tissues: Biological dissolving
Toxicity
