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分子马达不等间距四态跃迁模型 被引量：4

A Stochastically Unequal Interval Four-state Hopping Model of Molecular Motor
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摘要 用主方程方法研究分子马达一维周期性四态不等间距随机跃迁模型 ,得出稳态情况下分子马达的漂移速度V、扩散系数D及随机参数r,将三者随ATP的浓度 [ATP]及外力F的变化进行了曲线拟合 ,并同大量实验结果进行了比较 。 The stochastic master equation approach to molecular motor's directed motion is used and a periodic one-dimensional four-state stochastically unequal interval hopping model is studied. The drift velocity V, the diffusion constant D and the randomness parameter r of the steady state are all be obtained. By comparing the simulated curve with experiment about drift velocity V, diffusion constant D and randomness parameter r versus [ATP] and external load F, the kinetic behaviors of a molecular motor under external load F are qualitatively analyzed.
作者 展永 吴魏霞 赵同军 关荣华 梅俊平
机构地区 河北工业大学理学院
出处 《生物化学与生物物理进展》 SCIE CAS CSCD 北大核心 2003年第3期416-421,共6页 Progress In Biochemistry and Biophysics
基金 国家自然科学基金资助项目 ( 10 0 75 0 0 7) 河北省自然科学基金项目 ( 1980 2 7) 河北省博士基金项目 ( 0 0 5 470 0 1D)~~
关键词 分子马达 不等间距 跃迁模型 动力学 蛋白质 molecular motor hopping model randomness parameter
分类号 Q615 [生物学—生物物理学] Q51 [生物学—生物化学]
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参考文献11

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同被引文献47

  • 1Collins TR, Hammes GG, Hsieh TS. Analysis of the eukaryotic topoisomerase II DNA gate: A single-molecule FRET and structural perspective. Nucleic Acids Res, 2009, 37(3): 712-720.
  • 2Bates AD, Maxwell A. Energy coupling in type II topoisomerases: why do they hydrolyze ATP? Biochemistry, 2007, 46(27): 7929-7941.
  • 3Miller KG, Liu LF, Englund PT. A homogeneous type II DNA topoisomerase from HeLa cell nuclei. J Biol Chem, 1981, 256(17): 9334-9339.
  • 4Osheroff N, Shelton ER, Brutlag DL. DNA topoisomerase II from Drosophila melanogaster. Relaxation of supercoiled DNA. J Biol Chem, 1983, 258(15): 9536-9543.
  • 5Lindsley JE, Wang JC. On the coupling between ATP usage and DNA transport by yeast DNA topoisomerase II. J Biol Chem, 1993, 268(11): 8096-8104.
  • 6Baird CL, Harkins TT, Morris SK, Lindsley JE. Topoisomerase II drives DNA transport by hydrolyzing one ATP. Proc Natl Acad Sci USA, 1999, 96(24): 13685-13690.
  • 7Morris SK, Baird CL, Lindsley JE. Steady-state and rapid kinetic analysis of topoisomerase II trapped as the closed-clamp intermediate by ICRF-193. J Biol Chem, 2000, 275(4): 2613-2618.
  • 8Campbell S, Maxwell A. The ATP-operated clamp of human DNA topoisomerase II alpha: hyperstimulation of ATPase by "piggy-back" binding. J Mol Biol, 2002, 320(2): 171-188.
  • 9Harkins TT, Lindsley JE. Pre-steady-state analysis of ATP hydrolysis by Saccharornyces cerevisiae DNA topoisomerase II. 1. A DNA-dependent burst in ATP hydrolysis. Biochemistry, 1998, 37(20): 7292-7298.
  • 10Harkins TT, Lewis T J, Lindsley JE. Pre-steady-state analysis of ATP hydrolysis by Saccharomyces cerevisiae DNA topoisomerase II. 2. Kinetic mechanism for the sequential hydrolysis of two ATP. Biochemistry, 1998, 37(20): 7299-7312.

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生物化学与生物物理进展
2003年 第3期

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