摘要
目的:为进一步研究isoline的代谢和毒理,采用化学方法制备其代谢产物。方法:分别采用水解,氮氧化和脱氢化反应将isoline转化为与代谢和毒理研究相关类型的产物。结果与结论:成功地制备了五个化合物,其中两个为新化合物,其结构经UV,IR,MS和NMR分析得以鉴定。
AIM: To prepare the metabolic compounds of isoline for further investigation of its metabolism and toxicology. METHODS:The improved chemical procedures involving hydrolysis, N-oxidation and dehydrogenation were used to convert isoline to the compounds of closely related structural types, which may be formed by in vivo enzyme systems. RESULT and CONCLUSION: Five compounds were successfully prepared from isoline, in which two new compounds were determined as isoline N-oxide and dehydro-isoline by UV,IR,MS and by extensive use of NMR techniques.
出处
《中国天然药物》
SCIE
CAS
CSCD
2003年第1期21-23,共3页
基金
国家自然科学基金杰出青年基金资助项目(No.39825129)~~
关键词
Isoline
代谢物
制备
理化性质
毒理
Isoline
Metabolites
Dehydrogenation
Isoline N-oxide
Dehydro-isoline
