摘要
目的 :了解霜斑样病变与幽门螺杆菌感染及十二指肠溃疡的关系。方法 :比较胃镜下十二指肠溃疡、霜斑样病变、十二指肠炎、正常球粘膜的炎症、胃化生程度及其胃窦幽门螺杆菌密度 ;把接受胃镜复查的霜斑样病变随机分为抗幽门螺杆菌治疗与抑酸治疗两组 ,观察治疗结果。结果 :十二指肠球部不同病变的组织学炎症程度各不相同 (P <0 0 5 ) ,以霜斑样病变最重 ;胃化生程度及胃窦Hp密度均以十二指肠溃疡与霜斑样病变为高 ,但后二者间无显著差别 (P >0 0 5 ) ;4 2例霜斑样病变患者中 4周治疗后内镜复查 2 6例 ,抗Hp治疗组 1 2例均恢复正常 ,单纯抑酸治疗组 1 4例仍有 5例霜斑样病变且 1例伴发溃疡 (P <0 0 4 2 5 )。结论 :幽门螺杆菌感染的重度活动性十二指肠炎是十二指肠溃疡的病理基础 。
Objective:To learn the relationship of shimofuri lesion with Helicobacter pylori infection and duodenal ulcer(DU).Methods:Density of Helicobacter pylori(Hp)in gatric antral mucosa,degree of inflammation and gastric metaplasia(GM)in duodenal mucosa were measured in subjects endoscopically assessed as duodenal ulcer,shimofuri lesion,duodenitis and normal duodenal bulbs.All patients with shimofuri lesion were randomly divided into ranitidine suppressing acid group(ranitidine group)and ant i Hp therapy group(anti Hp group),then two groups were secondly observed with gas troscope.Results:Thc inflammation degree between various mucosa lesion cach other were different( P <0 05)and shimofuri lesion was the most serious duodenitis.Both the Hp density and the GM degree were no difference between DU and shimofuri lesion( P <0 05).26 subjects of 42 shimofuri were repeated endoscopy at 4 weeks.The endoscopic findings were 5 shimofuri lesion(lcom-plicated duodenal ulcer)in the ranitidine group(14) Vs 0 in the anit Hp group(12)( P <0 0425).Conclusions:serious active duodenitis resulted by Hp may be the pathological base of DU and shimof uri lesion may be a precursor of DU.
出处
《华西医学》
CAS
2003年第2期209-210,共2页
West China Medical Journal
关键词
霜斑样病变
胃上皮化生
HP感染
幽门螺杆菌
病理
helicobacter pylori
helicobacter/diagnosis
shimofuri lesion/diagnosis
shimofuri lesion/treatment
gastric metaplasia/pathology
