摘要
目的 :观察还原型谷胱甘肽 (GSH)对于恶性肿瘤患者在接受化疗时并发的化疗药物性肝损害的预防和治疗作用。方法 :采用对照研究 ,将 1 5 6例患者分为二组 ,预防组 (80例 )在化疗同时予以GSH ;对照组 76例单纯化疗 ,该组患者如出现肝损害则使用GSH治疗 (2 8例 )。观察比较两组患者在肝损害发生率、损害程度上的差异 ,并评价GSH治疗肝损害的疗效。结果 :预防组肝损害发生率 1 5 0 % ,Ⅲ /Ⅳ度肝损害 2 5 % ,对照组肝损害发生率 36 8% ,Ⅲ /Ⅳ度肝损害 1 2 2 % ,二组比较差异有显著性 (P均 <0 0 1 )。对照组中肝功能损害患者疗前、疗后ALT及AST值的变化有显著性 (P <0 0 1 )。结论 :GSH用于预防和治疗恶性肿瘤患者化疗药物性肝损害疗效显著 。
Objective:To observe and evaluate the efficacy of reduced glutathione(GSH)in the prevention and treatment of chemical hepatitis in patients with malignant tumor.Methods:All 156 patients with malignant tumors were randomly divided into two groups.Prevention group (80 cases)received both anti-tumor agents and GSH during treatment.The control group(76 cases)only received anti-tumor agents.The patients of the control group who had chemical hepatitis received GSH treatment(28 cases).Results:the rat of hepatotoxicity of the prevention group and control group was 15 6% and 36 8%,respectively( P <0 01).The rate of clinical efficacy of GSH was 89 3% in the control group and the valves of the ALT and AST before and after treatment were significantly different( P <0 01).Conclusion:GSH was effective and safe in the prevention and treatment of the hepatotoxicity caused by chemotherapy in patients having malignancy tumor.
出处
《华西医学》
CAS
2003年第2期190-191,共2页
West China Medical Journal
