摘要
目的:探讨非霍奇金淋巴瘤(NHL)中的微血管密度(MVD)及其与NHL恶性程度、免疫学类型、预后的关系;方法:采用生物素标记的荆豆凝集素I(Bio-UEA-I)免疫组化ABC法对102例NHL的MVD进行原位观察和数量分析;结果:MVD随NHL恶性程度的增高而增高,高度恶性组和中度恶性组MVD显著高于低度恶性组MVD;T细胞性NHL中的MVD显著高于B细胞性NHL也的MVD;短生存期组的MVD显著高于长生存期组的MVD;结论:NHL中的MVD可作为判断肿瘤恶性程度、免疫学类型及预后估计的有意义的指标,在临床病理中有实际应用价值。
Objective:To explore the relationship between the microvessel density (MVD) and the malignancy,immuno-types and prognosis of Non-Hodgkin's lymphoma (NHL). Methods:By using biotinated UEA-I (Bio-UEA-I) immunohis-tochemical ABC method,the MVD in 102 cases of NHL were detected. Results: MVD in high grade and middle grade NHL were significantly higher than that in low grade NHL;T cell NHL MVD was apparently higher than B cell NHL MVD,and MVD in short survival group was remarkably higher compared with that in long survival group. Conclusion: MVD in NHL can be a valuable parameter in assessing the malignancy degree,immunotypes and prognosis of NHL.
出处
《解剖学杂志》
CAS
CSCD
北大核心
2003年第1期51-54,共4页
Chinese Journal of Anatomy
