摘要
目的:探讨慢性乙型肝炎转氨酶顽固性不降患者的中医证型与IL-6、TNF-α的关系。方法:随机观察54例慢性乙型肝炎转氨酶顽固性不降患者,进行中医辨证分型,辨证论治加护肝降酶药治疗,检验治疗前后各证型患者血清IL-6、TNF-α水平及ALT、AST变化情况。结果:所有患者IL-6、TNF-α升高,经治疗后,ALT、AST复常者IL-6、TNF-α都降低。结论:转氨酶顽固性不降者以阴虚证为多见,与正虚邪恋有关。IL-6、TNF-α是介导肝细胞损伤,促进炎症反应,使慢性肝脏炎症持续存在,并导致纤维化形成的重要机制之一。
Objective: To study the relationship among syndrome types of TCM and serum IL-6、TNF-α in refractory chronic hepatitis B with excess of transaminase. Methods: The syndrome types of TCM and IL-6、TNF-α in 54 cases of refractory chronic hepatitis B with transaminase were observed randomly. Results: Serum IL-6、TNF-α of all patients were excess. After treating by TCM-WM, IL-6、TNF-αsame time serum ALT, AST were recovered to normal level. Conclusion: The most patients of Yin deficiency type have higher transaminase. The important mechanism are hepa-tocyte injury, inflammation response induced by IL-6、TNF-α, they make liver inflammation existence to last and lead to fibrosis.
出处
《中西医结合肝病杂志》
CAS
2003年第3期145-147,共3页
Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases
