摘要
目的了解食管癌组织中的促凋亡状况及其与抗肿瘤免疫的关系。方法采用免疫组化 L SAB法对 4 6例食管癌手术切除标本中的白细胞介素 1β转化酶 (IL- 1β converting enzyme,ICE)、Fas、Fas L 蛋白进行标记 ,并对其中 13例进行 Td T介导d UTP缺口末端标记。结果 ICE、Fas、Fas L蛋白在癌巢中的阳性率分别为 78.2 6 %、6 0 .87%和 4 7.83% ,ICE蛋白的表达程度与癌组织学分级有相关性。结论癌组织表达 Fas、Fas L,可能参与癌细胞的免疫逃避 ;ICE的表达与癌组织分化有一定关系。
ObjectiveTo study the relationship between the antitumor immunoreaction and the cell apoptosis in esophageal carcinoma.MethodsThe IL-1β converting enzyme, Fas and FasL protein were labeled by LSAB immunohistochemistric method in 46 cases of esophageal carcinoma, of which 13 cases were labeled by TdT mediated dUTP nick end labeling (TUNEL).ResultsThe positive rates of ICE, Fas and FasL proteins in the cancer nests were 78.26%, 60.87% and 47.83%. The expression of ICE protein was related to the histological grading of the cancer.Conclusions The expression of Fas, FasL protein may be related to the immunological escape of the cancer cell; the expression of ICE was related to the histological grading of the cancer.
出处
《中国康复理论与实践》
CSCD
2003年第6期344-345,355,共3页
Chinese Journal of Rehabilitation Theory and Practice
关键词
凋亡
食管癌
凋亡相关蛋白
apoptosis
esophageal carcinoma
apoptosis related protein
