摘要
目的 :分析比较尿核基质蛋白 2 2 (NMP2 2 )检测与尿脱落细胞学检查诊断膀胱移行细胞癌的临床价值。方法 :对 12 6例临床怀疑膀胱癌的病人 ,在膀胱镜检查前留取新鲜自排尿 ,分别进行NMP2 2检测和脱落细胞学检查 ,比较 2种方法的敏感性、特异性和阳性预测值。结果 :12 6例中病理证实膀胱移行细胞癌 35例 ,其他疾病 91例。NMP2 2诊断膀胱癌敏感性 82 .9% ,与细胞学 (2 5 .7% )比较 ,差别有极显著性意义 (P <0 .0 1)。即使对浅表性膀胱癌 ,NMP2 2的敏感性也达到 77.8% ,明显优于细胞学的 11.3% (P <0 .0 1)。 2种方法诊断特异性分别为 79.1%和 10 0 .0 %。阳性预测值分别为 6 0 .4 %和 10 0 .0 %。结论 :NMP2 2检测是一种简单、敏感的早期诊断膀胱癌的方法。
Objective:To evaluate the diagnostic value of urinary NMP22 and cytology in the detection of bladder transitional cell carcinoma.Methods:One hundred and twenty-six sympotomatic patients suspicious of bladder cancer were asked to take urinary NMP22 and cytological examination before cytoscopy.Results:Thirty-five patients were pathologically diagnosed as transitional cell carcinoma,and 91 cases were other urological conditions.The sensitivity of NMP22 (82.9%) was significantly better than urinary cytology (25.7%) , P <0.01.For superficial bladder cancer, the sensitivity of NMP22 was also better than cytology(77.8% versus 11.3%, P <0.01).The specificity of NMP22 and cytology was 79.1% and 100.0%,with the positive predictive values 60.4% and 100.0%.Conclusions:Urinary NMP22 value is a simple ,sensitive and early diagnositic marker for bladder transitional cell carcinoma.
出处
《中国现代医学杂志》
CAS
CSCD
2003年第11期10-12,共3页
China Journal of Modern Medicine
