摘要
目的 研究卡他莫拉菌的致病性及该菌在国内产 β 内酰胺酶和超广谱 β 内酰胺酶 (ESBLs)的情况。方法 抗菌药物敏感试验为纸片扩散法 ,β 内酰胺酶为Nitrocefin ,ESBLs确证试验为双纸片增效方法 ,均按NCCLS提出的标准实施。结果 从 86 0例各类标本中分离出 180株卡他莫拉菌 ,慢性阻塞性肺疾患 2 6 2 % ,支气管肺炎 2 7 5 % ,老年性上呼吸道感染 2 5 .8% ,耳鼻喉疾患 16 .3% ,皮肤科疾患 17 5 % ,小儿上呼吸道感染17 3% ,产β 内酰胺酶 83.88%、超广谱 β 内酰胺酶 11.1%。结论 卡他莫拉菌为条件致病菌 ,可引起多种感染性疾病 ,其致病性和耐药性都呈上升趋势 ,尤其对产酶卡他莫拉菌应引起临床的高度重视。
OBJECTIVE To study the pathogenicity and β-lactamases and extended-spectrum β-lactamases of the Moraxella catarrhalis. METHODS Diffusion test to measure antibiotic sensitivity, Nitrocefin to β-lactamases, efficient enhancing diffusion test to ESBLs were used. All were done under NCCLS standard. RESULTS A total of 180 strains of M. catarrhalis were isolated from 860 specimens. The infection rate in various diseases were as follows: 26 2% in COPD (chronic obstructive pulmonary disease), 27.5% in bronchopneumonia, 25.8% in senile upper respiratory tract infection, 16.3% in otorhinolaryngologic diseases, 17.5% in dermatologic diseases (nongonococcal), 17.3% in children upper respiratory infections. 83.88% of the M. catarrhalis produced β-lactamases, 11.1% produced extended-spectrum β-lactamases. CONCLUSIONS M. catarrhalis is an opportunistic pathogen. It can cause a lot of infectious diseases. The infection rate and drug resistance are increasing. A great attention to β-lactamases producing M. catarrhalis in clinic should paid.
出处
《中华医院感染学杂志》
CAS
CSCD
2003年第6期583-585,共3页
Chinese Journal of Nosocomiology
关键词
卡他莫拉菌
致病性
耐药性
ESBLS
Pathogenicity
Antibiotic resistance
Extended-spectrum β-lactamase
