摘要
目的了解大环内酯耐药卡他莫拉菌(MRMC)肺炎患者的临床特征,探讨其患病的危险因素。方法对2013年1月至2022年1月的32例MRMC肺炎患者和114例大环内酯敏感卡他莫拉菌(MSMC)肺炎患者信息进行回顾分析。结果卡他莫拉菌肺炎患者以男性为主(71.92%),≥65岁者居多(67.12%),冬春季高发(64.38%)。多因素logistic回归分析结果显示,女性(OR=2.77,95%CI:1.18~6.47)和陈旧性肺结核病史(OR=5.95,95%CI:1.31~31.57)是感染MRMC肺炎的独立危险因素。MRMC组患者发热(OR=2.87,95%CI:1.09~7.46)、C反应蛋白升高(OR=2.65,95%CI:1.12~6.63)、支气管炎(OR=4.00,95%CI:1.54~11.52)和肺气肿影像学表现(OR=5.73,95%CI:1.94~19.56)的比例显著高于MSMC组。结论女性和陈旧性肺结核病史是感染MRMC肺炎的独立危险因素,且MRMC组患者的症状、炎症和影像学表现更严重,应关注其临床诊治。
Objective To explore the clinical characteristics and risk factors of macrolide resistance Moraxella catarrhalis(MRMC)pneumonia.Methods From January 2013 to January 2022,the information of 32 patients with MRMC pneumonia and 114 patients with macrolides sensitive Moraxella catarrhalis(MSMC)pneumonia were retrospectively analyzed.Results The patients with Moraxella catarrhalis pneumonia were mainly men(71.92%)and aged≥65 years(67.12%).The incidence rate was high in winter and spring(64.38%).Multivariate logistic regression analysis showed that being woman(OR=2.77,95%CI:1.18–6.47)and the history of tuberculosis(OR=5.95,95%CI:1.31–31.57)were independent risk factors for MRMC pneumonia.The percentage of patients with fever(OR=2.87,95%CI:1.09–7.46),abnormal C-reactive protein(OR=2.65,95%CI:1.12–6.63),bronchitis(OR=4.00,95%CI:1.54–11.52),and emphysema(OR=5.73,95%CI:1.94–19.56)increased significantly in the MRMC group compared with the MSMC group.Conclusion Being woman and the history of tuberculosis were independent risk factors for MRMC pneumonia,and patients in the MRMC group had more severe symptoms,inflammation and pulmonary imaging manifestations,suggesting that attention should be paid to the clinical diagnosis and treatment of MRMC pneumonia.
作者
蒋艳
王静
秦天
连星星
汤睿智
卢忠心
徐建国
Jiang Yan;Wang Jing;Qin Tian;Lian Xingxing;Tang Ruizhi;Lu Zhongxin;Xu Jianguo(School of Public Health,Nanjing Medical University,Nanjing 211166,Jiangsu,China;The Central Hospital of Wuhan Affiliated to Tongji Medical College of Huazhong University of Science and Technology,Wuhan 430014,Hubei,China;State Key Laboratory of Communicable Disease Prevention and Control,National Institute for Communicable Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 102206,China;School of Public Health,Shanxi Medical University,Taiyuan 030001,Shanxi,China)
出处
《疾病监测》
CAS
CSCD
北大核心
2022年第5期635-640,共6页
Disease Surveillance
关键词
卡他莫拉菌
大环内酯类抗生素
耐药
危险因素
临床特征
Moraxella catarrhalis
Macrolides
Drug resistance
Risk factor
Clinical characteristics
