摘要
分析了SARS病毒攻击肺泡组织的耗氧模式,提出缓解SARS病毒侵害的热氧灌注疗法,建立支气管末端肺泡组织的传热模型,对肺泡组织在不同热氧灌注条件下的温度响应进行理论分析。结果表明,显著温升主要发生于肺泡壁即病毒聚集区。由于病毒复制需要通过其所攻击的宿主细胞的酶进行,因而通过热氧灌注造成的温度改变可望有效地削弱该处细胞酶的催化特性,继而抑制病毒的活性,同时又能将氧气通过肺泡壁供应到人体组织内。从临床实用性出发,进一步讨论了相应的热氧灌注措施,为SARS患者临床治疗提供了一种新的物理疗法治疗思路。
Oxygen consumption mode for the SARS (severe acute respiratory syndrome) virus to attack alveolus tissue was analyzed and hot oxygen ventilation (HOV), a new method for remission of the invasion of SARS, was put forward. Then Heat transfer model of alveolus tissue at the end of the bronchia was established in attempt for the theoretical analysis on temperature response in the tissues under various oxygen ventilation conditions. It was shown that evident temperature increase occurred mainly at the collective area of the alveolus wall, where virus accumulated densely. Since replication of virus greatly depends on the enzyme of the host cell it attacked, the varied temperature level due to HOV can possibly lower the catalysis effect of enzyme and thus depress the viability of the SARS virus there. Meanwhile, oxygen can still be availably supplied for the tissues via the alveolus wall. Strategy to operate the HOV is further discussed from the clinical point of practicability, for purpose of providing a new technical approach for rehabilitation of SARS in clinics.
出处
《中国临床康复》
CSCD
2003年第12期1745-1747,共3页
Chinese Journal of Clinical Rehabilitation
关键词
热氧灌注
SARS
可行性
非典型肺炎
物理疗法
传染病
SARS
hot oxygen ventilation
clinical rehabilitation
bioheat transfer
hyperthermia therapy
oxygen transport
