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曲美他嗪治疗缺血性心脏病研究进展 被引量：1

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摘要 目前缺血性心脏病的治疗方法较多,主要包括以下三类:抗心肌缺血药物,如β阻滞剂、钙拮抗剂、硝酸酯类药物等;冠状动脉介入治疗;冠状动脉旁路移植术(CABG).
作者 董晓冬 贾三庆
机构地区 首都医科大学附属北京友谊医院
出处 《中国医药导刊》 2003年第3期215-217,共3页 Chinese Journal of Medicinal Guide
关键词 曲美他嗪 治疗 缺血性心脏病 稳定型心绞痛 抗心肌缺血药物 临床应用 急性心肌梗死
分类号 R541 [医药卫生—心血管疾病]
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参考文献22

  • 1周国鹏,赵志杰,祁芸芸.三甲氧苄嗪对低流量灌流大鼠心肌细胞葡萄糖转运蛋白-1、4mRNA表达的影响[J].中国医药导刊,2001,3(5):380-382. 被引量：1
  • 2中国曲美他嗪多中心临床研究协作组,胡大一,赵秀丽.曲美他嗪对稳定性劳力型心绞痛的疗效观察[J].中华心血管病杂志,2000,28(5):339-341. 被引量：173
  • 3程艳丽,胡大一,李瑞杰,刘晓惠,李俊华,李忠莉.曲美他嗪治疗稳定型心绞痛的疗效观察[J].中国医药导刊,2001,3(4):280-281. 被引量：6
  • 4马琦琳,谢勇,张赛丹,彭道地,曾小林.心力衰竭患者氧自由基的变化及万爽力对其的影响[J].湖南医科大学学报,2002,27(6):527-529. 被引量：32
  • 5Taegtmeyer H, King LM, Jones BE. Energy substrate metabolism,myocardial ischemia, and targets for pharmacotherapy. Am J Cardiol,1998; 82(5A) : 54K - 60K.
  • 6Kantor PF,Lucien A, Kozak R, et al. The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long - chain 3 - ketoacyl coenzyme A thiolase. Circ Res, 2000; 86(5): 580-588.
  • 7Minners J, van - den - Bos EJ, Yellon DM, et al. Dinitmphenol, cyclosporin A, and trimetazidine modulate preconditioning in the isolated rat heart: support for a mitochondrial role in cardioprotection. Cardiovasc Res, 2000; 47(1): 68-73.
  • 8El Banani H, Bernard M, Baetz D, et al. Changes in intracellular sodium and pH during ischaemia - reperfusion are attenuated by trimetazidine.Comparison between low-and zero- flow ischaemia. Cardiovasc Res,2000; 47(4) : 688-696.
  • 9Szwed H, Sadowski Z, Elikowski W, et al. Combination treatment in stable effort angina using trimetazidine and metoprolol: results of a randomized, double-blind, multicentre study (TRIMPOL Ⅱ). TRIMetazidine in POLand. Eur Heart J, 2001 ; 22(24) : 2267 - 74.
  • 10Manchanda SC. Treatment of stable angina with low dose diltiazem in combination with the metabolic agent trimetazidine. Int J Cardiol, 2003;88(1) : 83-89.

二级参考文献36

  • 1[1]Michaelides AP, Spiropoulos K, Dimopoulos K, et al. Antianginal efficacy of the combination of trimetazidine - propranolol compared with isosorbide dinitrite - propranolol in patients with stable angina. Clin Drug Invest, 1997; 13:8 ～ 14
  • 2[2]Szwed H, Pachocki R, Domzal - Bochenska M, et al. Efficacy and tolerance of trimetazidine in combination with a conventional antianginal drug in patients with stable effort angina. Diagn treat Cardiol, 1997;4:237 ～ 247
  • 3[3]Levy S, Group of South of France Investigators. Combination therapy of trimetazidine with diltiazem in patients with coronary artery disease. Am J Cardiol, 1995 Aug 24;76: 12B ～ 16B
  • 4[4]Sellier P, Audouin P, Payer B, et al. Acute effects of trimetazidine evaluated by exercise testing. Eur J Clin Pharmacol, 1987;33:205 ～ 207
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  • 6[6]Mody FV, Singh BN, Mohinddin IH, et al. trimetazidine - induced enhancement of myocardial glucose utilization in normal and ischemic myocardial tissue: an evaluation by positron emission tomography. Am J Cardiol, 1998;82:42K ～ 49K
  • 7[7]Guarnieri C, Finelli C, Zini M, et al. Effects of trimetazidine on the calcium transport and oxidative phosphorylafion of isolated rat heart mitochondrial function. Basic Res Cardiol, 1997 Apr; 92: 90 ～ 95
  • 8[8]Catroux P, Benchekroun N, obert J, et al. Influence of trimetazidine on deleterious effect of oxygen radical species in postischemic acute renal failure in the rat[abstract].Cardiovasc Drugs Ther, 1990;4 supp1,4:816 ～ 817
  • 9[9]William FM, Tanda K, Kus M. trimetazidine inhibits neutrophil accumulation after myocardial ischemia and reperfusion in rabbits. J cardiovasc Pharmacol, 1993; 22:828 ～ 833
  • 10Slot JW, Geuze HJ, Gigengack S, et al. Translocation of the glucose transporter GLUT4 in cardiac myocytes of the rat. Proc Nad Acad Sci USA 1991;88:7815 ～ 7819

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中国医药导刊
2003年 第3期

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