摘要
目的 :研究广泛焦虑障碍 (GAD)患者的心理社会因素、免疫学特点及这二者之间的相互关系。方法 :研究组为 3 0例GAD患者 ,对照组为 2 5例抑郁性神经症 (DN)患者及 3 2例健康人。所有样本均用生活事件量表 (LES)测评生活事件应激 ,用简易应对方式问卷 (SCSQ)评定应对方式 ,用艾森克个性问卷 (EPQ)评定人格特征 ,测血清白介素 -2 (IL -2 )浓度 ,自然杀伤细胞 (NK)及CD3 +细胞比率测定。比较GAD与DN、正常对照组 (NCG)二组的差异 ,并对GAD内部有关指标进行相关分析。结果 :GAD组患者LES评定中 ,负性事件数及LEU值水平小于DN组 ,生活事件发生的总件数、负性事件数、负性事件LEU值均大于正常组。应对方式中 ,积极应对维度少于正常组 ,消极应对维度多于DN组及正常组。EPQ评定中 ,无论男女N分均大于正常组 ,与DN组无显著性差异。IL -2大于DN组及正常组。CD3 +及NK比例与其它两组均无显著性差异。IL -2与生活事件总件数、EPQ中L分呈负相关 ,与NK呈正相关。结论 :GAD患者有明显的心理社会应激、消极的应对方式、情绪不稳定 ,存在着部分免疫功能异常。心理社会因素对免疫学有影响。
Objective: To study psychosocial factors and immunity of patients with generalized anxiety disorder Method: 30 patients with generalized anxiety disorder (GAD), 25 patients with neurotic depression and 32 normal controls were collected and assessed with LES (life event scale), SCSQ (simplified coping style questionnaire) and EPQ (Eysenck personality questionnaire) The blood level of IL-2, and rates of NK cell and CD3+ cell of them were also measured Result: The number of negative life events and LEU of negative life events of GAD group were higher that of normal controls, but lower than that of neurotic depression group Their total life events were also more than that of normal controls They had less positive coping than normal controls, more negative coping than both normal controls and patients with neurotic depression Their N score of EPQ was higher than that of normal control and had no significant different to that of patients with neurotic depression They also had higher levels of IL-2 than that of the other two groups There was no significant difference in rates of NK cell and CD3+ cell among all three groups The level of IL-2 was negatively correlated to the number of total life events and L score of EPQ, positively correlated to the rate of NK cell Conclusion: Patients with GAD have psychosocial stress in their life, they incline to negative coping, having unstable mood and impaired immune function Psychosocial stress has influence on immunity
出处
《中国心理卫生杂志》
CSSCI
CSCD
北大核心
2003年第6期397-400,共4页
Chinese Mental Health Journal
基金
浙江省湖州市科委资助项目 (编号 :2 0 0 0YS1 4 )的子课题
