摘要
目的观察康莱特(KLT)缓解晚期肺癌患者疼痛及对体重的影响,探讨其对晚期肺癌患者生活质量改善方面的作用。方法选择沈阳军区总医院肿瘤科和辽宁省肿瘤医院内一科2002-01/2003-01符合入组条件的81例晚期肺癌患者,采用前瞻性随机对照研究方法,将患者以随机数字表法分为治疗组41例(康莱特注射液100ml,静脉滴注,1次/d,连续30d加2周期NP方案)和对照组40例(单用2周期NP方案),分别观察化疗后疼痛、体重、karnofsky评分等。结果收治87例非小细胞肺癌患者,可评价疗效81例,在控制疼痛、体重增加、提高生活质量方面,治疗组均优于对照组,差异有显著性(χ2=6.6540,P=0.0357;χ2=7.0450,P=0.0295;χ2=10.1101,P=0.064)。结论康莱特注射乳剂,能缓解疼痛症状,改善晚期癌症患者的生活质量。
Aim To observe the influence of Kongloite (KLT) on pain and body weight in patients in remission advanced stage and explore effect on life quality.Methods 81 patients with lung cancer in advanced stage treated in department of tumor,General Hospital of Shenyang Military Region and first department of internal medicine,tumor hospital of Liaoning Province from January 2002 to January 2003 were investigated and prospective random control study was used.Subjects were divided into treatment group(Kongloite injection 100 ml by venous,once a day for 30 days and 2 cycles of NP programs combined,n=41) and control group(simple 2 cycles of NP programs,n=40) by random number table.Pain,body weight,Karnofsky score were observed after chemotherapy.Results 87 cases of small cell carcinoma of lung were included among which therapeutic effects might be assessed.At pain control,increasing of body,therapeutic effects in treatment group were superior to those in control group and there was significant differences(χ2=6.6540,P=0.0357,χ2=7.0450,P0.0295,χ2=10.1101,P=0.064). Conclusion Injective emulsion can relieve pain and improve life quality of patients with lung cancer in advanced stage.
出处
《中国临床康复》
CSCD
2003年第11期1672-1673,共2页
Chinese Journal of Clinical Rehabilitation
