摘要
取健康家兔 10只 ,随机分为 2组 ,单剂量静脉注射游离儿茶素 (Catechin)和儿茶素脂质体 (Catechin L iposom e) 2 5mg/ kg。用高效液相色谱法测定血浆中儿茶素原药质量浓度。房室模型分析表明 ,健康家兔静脉注射游离儿茶素的药时数据符合无吸收二室开放模型 [5～ 6 ] ,主要动力学参数为 :t1 /2α0 .15± 0 .0 1h,t1 /2β0 .5 8± 0 .0 2 h,维生素 C 1.4 1± 0 .0 8L ,维生素 B 2 .97± 0 .11L,Cl B3.5 3± 0 .10 L/ h,AUC16 .95± 1.5 2 L· h,K1 0 2 .5 2± 0 .2 0 h,K2 1 2 .2 5± 0 .15 h,K1 2 1.17± 0 .15 h。健康家兔静脉注射儿茶素脂质体的药时数据亦符合无吸收二室开放模型 ,主要药物动力学参数为 :t1 /2α 0 .18± 0 .0 1h,t1 /2β1.5 2± 0 .0 8h,维生素 C 1.2 5± 0 .10 L ,维生素 B 4 .4 8± 0 .2 4 1,Cl B2 .0 5± 0 .0 7L / h,AUC 2 9.2 0± 1.0 0 L· h,K1 0 1.6 4± 0 .16 h,K2 1 1.0 87±0 .0 6 h,K1 2 1.6 1± 0 .19h。试验结果表明 :儿茶素经脂质体包封后 ,药物动力学及组织分布均发生了明显的改变。
Pharmacokinetis of catechin were studied in 10 healthy rabbits following single intravenous(25 mg/kg) free and liposome catechin of the plasma. catechin concentrations were determined by high-performance liquid chromatography. The concentration-time data were fitted to a two-compartment model following a single intravenous injection in rabbits. The main pharmacokinetic parameters were as follows:distribution half-life(t 1/2α ) 0.15±0.01 h, elimination half-life(t 1/2β ) 0.58±0.02 h, apparent distribution volume(Vd) 2.97±0.11 L total body clearance(Cl B) 3.53±0.10 L/h, the area under curve(AUC) 16.95 ±1.52 mg/(L·h). The drug concentration-time data also were fitted to a two-compartment open model after a single intrarenous-catechin liposome. The pharmacokinetic parameters were as follows: t 1/2α 0.18±0.01 h, t 1/2β 1.52±0.08 h,V C 1.25±0.10 h, Cl B 2.05±0.01 mg/L, AUC 29.20±1.00 mg/(L·H).The results showed that the pharmacokinetic characteristics and tissue distribution of catechin were significant changes observed.
出处
《中国兽医杂志》
CAS
北大核心
2003年第4期46-48,共3页
Chinese Journal of Veterinary Medicine
