摘要
以四氧嘧啶糖尿病小鼠为模型探讨了细胞免疫状态的变化。结果显示,四氧嘧啶糖尿病小鼠脾淋巴细胞DNA合成减少,IL-2产生降低。自然杀伤活性细胞功能减弱,表现为体内YAC-1细胞清除速率延缓。将糖尿病鼠脾淋巴细胞悬浮于含一定量胰岛素的培养液内,其细胞增殖应答活性明显升高,IL-2产生显著增多。提示胰岛素可能是一种重要的免疫调节激素。
In this paper, we report the status of cellular immune in alloxan diabetic mice. It is shown that the cleaning percentage of YAC- 1 cell in the organs (lung,liver,blood) in alloxan diabetic mice is remarkably decreased. The spleen lymphocytes proliferation response to Con A and the production of IL- 2 are significantly inhibited. Insulin could modulate the proliferation response and IL- 2 production in vitro. The results suggest that insulin is one of the most important immunoregulaticn hormone and play an important role in the regulation of immune system.
出处
《基础医学与临床》
CSCD
1992年第5期299-303,共5页
Basic and Clinical Medicine
关键词
胰岛素
糖尿病
细胞免疫
insulin diabetic mice cellular immune
