摘要
对32例原发性高血压患者的 T 细胞亚群及多项细胞免疫指标、自身抗体进行检查和分析,结果显示该病患者的 CD_3、CD_4、CD_8 细胞百分率均有不同程度降低,其中以 CD_8 降低和 CD_4/CD_8 比值上升最为明显,并与病期的严重程度有关,同时还伴有大颗粒淋巴细胞百分率降低及 B 细胞的升高。提示CD_8、大颗粒淋巴细胞数量减少及功能低下,可能是原发性高血压患者免疫功能紊乱的重要环节,由其所导致的免疫损伤可能是该病发病机制中的一个致病因素。本文还对该病患者中自身抗体检出意义作了探讨。
Thirty-two cases of primary hypertension were studied for analyzing subsets ofIymphocytes and disturbances of cyto-immunologic and autoantibody indices.It wasindicated that CD_3,CD_4,CD_8 cells decreased in association with the increase of Bcell and CD_4/CD_8 ratio in patients with primary hypertension,especially significantwere in CD_8 cell,while the number of large granule lymphocytes(LGL)decreasedand ratio of CD_4/CD_8 increased significantly.The result suggested that both decreaseof number and hypofunction on CD_8 LGL were important links of disturbancesof immunologic function in patients with primary hypertension,as well as an patho-logic factor in the etiology of hypertension.
出处
《天津医药》
CAS
1991年第11期650-653,共4页
Tianjin Medical Journal
关键词
高血压病
免疫学
细胞免疫
hypertension
immunology
cyto-immunology
T-lymphocytes
