摘要
本文以L-谷氨酸为原料合成了(1S,5S)和(4S,5R)-Muricatacin,并以该两化合物的NMR和[α]_D数据确证了Annonacin中四氧呋喃段的四个手性中心为(15R,16R,19R,20R).
The synthesis of (+)-(4S, 5S)-muricatacin and its (4S, 5R) isomer from L-(+)-glutamic acid as starting material is reported. Natural muricatacin is confirmed as a threo mixture major in (422, 522) configuration and hence the absolute configuration of the tetrahydrofuran segment of annonacin is (15R, 16R, 19R, 20R) by comparison of the NMR and optical rotations.
出处
《化学学报》
SCIE
CAS
CSCD
北大核心
1992年第9期901-904,共4页
Acta Chimica Sinica
