摘要
目的:探讨青黛颗粒治疗溃疡性结肠炎(UC)的机制。方法:应用2,4-二硝基氯苯法建立大鼠UC模型,检测青黛颗粒治疗后UC大鼠结肠组织中超氧化物歧化酶(SOD)、过氧化氢酶(CAT)活性和脂质过氧化产物丙二醛(MDA)的含量变化。结果:青黛颗粒组UC大鼠结肠组织中SOD活性升高(P<0.05),MDA含量显著降低(P<0.05),CAT活性有增高趋势(P>0.05)。结论:青黛颗粒具有清除结肠组织中的氧自由基,抑制脂质过氧化反应的作用。
Objective: To study the mechanism of Qingdai granule (QG) in treating ulcerous colonitis (UC). Methods: Rat model of UC was made by the method of 2,4-dinitrochlorobenzene. Contents of tissue superoxide dismutase (SOD) , catalase (CAT) activity and level of malondialdehyde (MDA) produced by tissue lipid peroxide were measured. Results: In the group treated with QG, the SOD activity increased ( P <0. 05) and the level of MDA reduced significantly ( P <0. 05). Conclusion: QG could resist lipid peroxidation by clearing oxygen radical.
出处
《中国中西医结合消化杂志》
CAS
2003年第3期144-145,共2页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
基金
辽宁省自然科学基金(No.972261)
沈阳市社会发展基金(No.9849340513)
