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大肠杆菌DNA作佐剂的鸡新城疫灭活疫苗的免疫效果 被引量:5

Immune enhancement of E.coli DNA on inactivated Newcastle disease vaccine in chickens
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摘要 用大肠杆菌DNA作为鸡新城疫灭活苗的佐剂接种 15日龄雏鸡 ,以鸡新城疫油乳剂灭活苗为对照 ,用血凝抑制实验检测病毒特异性血凝抑制抗体。结果表明 ,大肠杆菌DNA及油乳剂两种佐剂均能增强特异性血凝抑制抗体的效价 ,二者组间抗体滴度差异不显著 ,但大肠杆菌DNA佐剂组雏鸡的体重明显高于油乳佐剂组 (P <0 0 1)。 E coli DNA and oil adjuvant were separately injected into chickens of 15 day old,together with inactivated Newcastle disease virus(NDV).Hemaggtulination inhibition test was performed for detecting specific antibody to NDV in sera of inoculated chickens.The results showed that all fowls developed specific antibody,and there were not significant difference of the antibody titres between E coli DNA group and the oil adjuvant group by statistical analysis ( P <0 05).But the weight of chickens inoculated with E coli DNA was higher than that of chickens inoculated with oil adjuvant ( P <0 01).
出处 《南京农业大学学报》 CAS CSCD 北大核心 2003年第2期76-78,共3页 Journal of Nanjing Agricultural University
基金 江苏省兽医生物技术中心开放课题
关键词 大肠杆菌DNA 新城疫 灭活疫苗 佐剂 免疫效果 抗体效价 E coli DNA Newcastle disease virus chickens immune enhancement
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  • 1李杰,杨汉春,郭鑫,陈艳红,查振林.CpG ODN对鸡新城疫LaSota活疫苗的免疫增强效应[J].畜牧兽医学报,2006,37(1):44-49. 被引量:13
  • 2宋新宇,张七斤,张和平,孟和毕力格.乳酸杆菌DNA对鸡新城疫油苗和禽流感油苗免疫增强作用的研究[J].中国动物检疫,2006,23(12):24-27. 被引量:2
  • 3颜伟,丁国富,李斌,董燕,李军,和生琦,罗平,周红,庞学利.CpG ODN107增强人脑胶质瘤细胞放射敏感性的研究[J].西南国防医药,2007,17(2):135-138. 被引量:9
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