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骨髓基质干细胞移植与心肌重建研究进展 被引量：8

Transplantation of bone marrow stromal stem cells and myocardial reconstruction
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摘要 骨髓基质干细胞是来源于骨髓的多能干细胞,在体、内外能分化成多种起源于中胚层的组织。其分化与其周围环境变化有关,可能需要一系列调控因子的参与。哺乳动物心肌从中胚层发育而来。在出生后早期,心肌细胞的增殖能力丧失,又没有相应的干细胞,损伤后心肌细胞不能再生。因而,心肌损伤后(如心肌梗死),常导致心肌细胞的不可逆性丢失和永久的功能丧失。植入外源性细胞是一个修复损伤心肌的、具有潜在临床应用价值的方法。骨髓基质干细胞在体、内外可诱导分化为肌源性细胞或心肌细胞。骨髓基质干细胞移植可以重建心肌,逆转左室重构,改善心功能,为心肌梗死提供一种新的治疗选择,有广阔的临床应用前景。
作者 崔继福 吴宗贵 赵学
机构地区 解放军第二军医大学长征医院心内科
出处 《中国临床康复》 CSCD 2003年第9期1417-1419,共3页 Chinese Journal of Clinical Rehabilitation
关键词 骨髓基质干细胞移植 心肌重建 心肌细胞 心肌损伤 心肌梗死
分类号 R457.7 [医药卫生—治疗学] R542.22 [医药卫生—心血管疾病]
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参考文献38

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同被引文献41

  • 1张钰聪,刘洪军,孟琛,吴晓光,汤哲.北京城乡老年人高血压与抑郁的关系[J].中华老年心脑血管病杂志,2006,8(8):520-523. 被引量：26
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引证文献8

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中国临床康复
2003年 第9期

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