摘要
目的检测了40例喉癌及喉正常声带组织的抗凋亡基因bcl-2,探讨其与术后生活质量相关性。方法采用免疫组化多重PAP方法进行检测。结果40例喉癌组织中15例bcl-2阳性,占37.5%。阳性反应主要位于喉癌细胞中,呈棕黄色细颗粒状。6例喉正常组织中1例阳性,阳性反应于腺体中。bcl-2表达阳性组比阴性组生存曲线明显下降,死亡危险度提前1～4年。结论bcl-2表达与喉癌患者术后生活质量和预后生存率有关。
Aim In this study ,40cases of Laryngeal c arcinoma and6cases normal laryngeal tissue bcl-2were tested with PAP immunohisto-chemical method.Methods 15of 40laryngeal carcinoma were positive for bcl-2,with a positive rate of 37.5%.Apoptosis-suppressing oncoprotein positive reaction products were bro wnish yellow granules,mainly locat ed in the cellular of laryngeal cancer cells,one of the six normal laryngeal tissue was positive,which was located in th e glandular tissue.Results The survival curve of the bcl-2positive group were lower than that of the negative group.The risk of mortalit y was 1-4years early.Conclusion The expression and clinical significant prognosis of bcl-2was related t o the survival rate of post-operation of l aryngeal cancer.
出处
《中国临床康复》
CSCD
2003年第8期1264-1265,共2页
Chinese Journal of Clinical Rehabilitation
