摘要
抗凋亡基因Ｂｃｌ－２的表达可抑制细胞凋亡过程，是导致肿瘤发生的因素之一。采用免疫组化多重ＰＡＰ方法，检测了３５例喉癌及５例喉正常声带组织的Ｂｃｌ－２。Ｂｃｌ－２阳性反应主要位于喉癌细胞中，呈棕黄色细颗粒状。３５例喉癌组织中１３例Ｂｃｌ－２阳性，占３７．１％。５例喉正常声带组织中１例阳性，阳性反应位于间质中。结果提示Ｂｃｌ－２表达阳性组和阴性组术后生存曲线有明显不同，Ｂｃｌ－２表达阳性组比阴性组生存曲线明显下降，死亡危险度峰值提前１～４年出现，Ｂｃｌ－２表达与喉癌术后生存率有关。
The expression of apoptosis suppressing oncoprotein Bcl 2 can block the apoptosis process of the cells, which is one of the factors that cause the development of tumor.The Bcl 2 in 35 cases of laryngeal carcinoma and 5 normal laryngeal tissue were tested with PAP immunohistochemical method. Bcl 2 positive reaction mainly occurred in the cells of laryngeal cancer and produced brownish yellow granules. Of the 35 laryngeal carcinoma tissue,Bcl 2 in 13 (37 1%) cases showed positive reaction. Of the five normal lanyngeal tissue, Bcl 2 in one case showed positive reaction,which occurred in the interstitial tissue. The results showed that the survival curve of the Bcl 2 positive group was significantly lower than that of the negative group. The risk of mortality was 1 4 years earlier, the expression of Bcl 2 was related to the survival rate of post operation of laryngeal cancer.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
1997年第2期110-112,共3页
Medical Journal of Chinese People's Liberation Army
