摘要
目的 探讨C -erbB - 2基因在非小细胞肺癌 (NSCLC)形成和进展中的作用。方法 应用免疫组织化学技术 (SP法 )检测 30例NSCLC和 10例正常肺组织中C -erbB - 2基因的表达情况。结果 C -erbB - 2基因在正常肺组织中未见表达 (0 / 10 ) ,在肺鳞癌表达率为 6 .3% (1/ 16 ) ,肺腺癌为5 0 .0 % (7/ 14 ) ,后两者差异显著 (P<0 .0 5 )。在病理组织学分级为Ⅰ级分化中的表达率为 0 % (0 / 9) ,Ⅱ级分化为 15 .3% (2 / 13) ,Ⅲ级分化为 75 .0 % (6 / 8) ,C -erbB - 2基因在不同组织学分级中的表达差异明显 (P <0 .0 5 ) ;在有淋巴结转移组为 4 3.8% (7/ 16 ) ,无转移组为 7.14 % (1/ 14 ) ,两者差异显著 (P <0 .0 5 )。结论 C -erbB -
Objective To study the effects of C-erbB-2 in the tumorous development and progression of non-small cell lung cancer (NSCLC). Methods 10 samples of paraffin-embedded normal lung tissues and 30 samples of paraffin-embedded tumors from patients with NSCLC were examined for C-erbB-2 expression by immunohistochemical methods. Results C-erbB-2 was underexpressed in normal lung tissues and overexpression in NSCLC. Overexpression of C-erbB-2 between lung squamous cell carcinomas and adenocarcinomas had obvious difference (P<0.05). The difference was also significant (P<0.05) among histologic grades Ⅰ, Ⅱand Ⅲ, and between the cases with and without lymph node metastasis. Conclusions The results suggest that C-erbB-2 may play an important role in the development and progression of NSCLC,and the detection of C-erbB-2 expression might be helpful to judge the metastasis of NSCLC and to predict the prognosis of patients with NSCLC.
出处
《齐齐哈尔医学院学报》
2003年第3期244-245,共2页
Journal of Qiqihar Medical University
