摘要
以已有实验与临床研究为依据 ,提出糖皮质激素受体 (GR)是虚证相关蛋白之一的理论假说。分析了进一步深入研究论证的途径 :①改进糖皮质激素受体检测方法 ;②应用酵母双杂交检测技术 ,了解GRβ与GRα之间的相互作用 ,并分析这些作用特征与阴虚、阳虚之间的关系 ;③运用良好的前瞻性设计 ,对临床虚证患者进行大量、反复的检测观察与统计分析。指出对该假说的研究论证 ,很有可能在蛋白质 (受体 )水平为中医证的微观诊断提供一个符合中医基本理论 ,具有现代科学依据的检测指标 。
This paper presents a hypothesis that glucocorticoid receptor(GR)is one of deficiency-syndrome relevant proteins on the basis of previous experimental and clinical studies,and approaches to further researches:①improving assay methods of GR;②applying yeast two-hybrid assay to determine the interaction between GRβ and GRα,and the mutual relationship of actions with yin deficiency and yang deficiency;③applying good prospective designs to make numerous detection and statistical analyses of the patients with deficiency syndromes.It is pointed out that the demonstration of the hypothesis probably provides a modern scientific index at the level of protein as micro-diagnosis conforming to the basic theories of Chinese medicine,in which some drugs may be found to elevate the content of GR.
出处
《上海中医药杂志》
北大核心
2003年第5期8-10,共3页
Shanghai Journal of Traditional Chinese Medicine
基金
自然科学杰出青年基金资助项目 ( 3 0 0 2 5 0 45 )
关键词
糖皮质激素受体
虚证
相关蛋白
阴虚证
阳虚证
Glucocorticoid receptor(GR)
deficiency syndrome
yin-deficiency syndrome
yang-deficiency syndrome
