摘要
目的 探讨幽门螺杆菌(Helicobacter pylori,HP)对消化性溃汤(Peptic ulcer,PU)患者热休克蛋白60(Heat shock pro-rein 60,HSP60)的影响。方法 观察HP清除率,运用Western斑点印迹技术对患者血清及胃黏膜匀浆HSP60进行检测,并将相关结果进行比较。结果 HSP60含量治疗前与对照组比较,HP阳性者明显增高(P<0.01);治疗后HP阳性者仍明显高于HP阴性者及HP清除者(P<0.05),而后两者无明显差异。结论 HP感染可促进HSP60表达,HP清除使HSP60表达能力下降,HP与HSP60存在关联。
Objective To study the influence of Helicobacter pylori (HP) on heat shock protein 60 (HSP^o) in patients with peptic ulcer. Methods HP clearance was investigated,and HSP60 in serum and gastric mucosa was assayed by Western dot blot. Results Compared with control group,the contents of HSP60 before treatment increased significantly in HP negative( P < 0.05) and HP positive patients ( P < 0.01); after treatment, HSP60 content was higher in HP positive patients than in HP negative and HP eradicated patients ( P < 0.05); there was no sisnificant difference between the latter two groups ( P > 0.05). Conclusions HP infection promotes the expression of HSP60, and HP clearance decreases the expression,thus correlation existing between HP and HSP60.
出处
《武警医学》
CAS
2003年第4期203-205,共3页
Medical Journal of the Chinese People's Armed Police Force
基金
国家中医药管理局重点资助项目(95B151)
