摘要
目的 :通过测定鼻咽癌 (NPC)患者外周血血清中超氧化物歧化酶 (SOD)活性和脂质过氧化物 (LPO)含量以及肿瘤坏死因子 -α(TNF -α)的水平 ,探讨其在鼻咽癌发病机理和肿瘤免疫方面的作用。方法 :采用比色法测定 86例NPC患者和 6 5例正常对照者血清中SOD活性和LPO含量 ;用双抗夹心ELISA法分别测定其血清中TNF -α水平。结果 :鼻咽癌患者外周血血清中LPO含量非常显著高于正常对照组 (P <0 .0 0 1) ,SOD活性非常显著低于正常对照组 (P <0 .0 0 1) ,而TNF -α水平显著高于正常对照组 (P <0 .0 1) ,血清中LPO含量和TNF -α水平呈高度正相关 (LPO含量的P值 <0 .0 0 1,TNF-α的P值 <0 .0 1) ,而SOD活性则相反 (P值 <0 .0 0 1)。结论 :鼻咽癌患者外周血血清中SOD活性和LPO含量及TNF -α水平的联合检测 ,有助于了解鼻咽癌患者的机体免疫状态 ,对探讨鼻咽癌的发病机制、病情判断、转归、预后以及临床治疗有指导意义和价值。
Objective:The purpose of the study was to approach the effect of Super oxide dismutase(SOD). Lipid per oxidation and tumor necrosis factor-α(TNF-α) in mechanism and tumor immune of nasopharynageal carcinoma(NPC) ,though determining the activation of Super oxide dismutase, the content of Lipid per oxidantion and the level of Tumor necrosis factor-αin NPC patient serum. Methods:To determine the activation of SOD and the content of LPO in 86 patients compared to that of 65 normal cases by colorimetry , and the level of TNF-α by ELISA . Results:The content of LPO in NPC group's serum were very significant higher than that in normal group (P<0.001) and the activation of SOD was very significant lower than the compared group's, the level of TNF-α was significantly higher than that of normal group. The content of LPO in serum was highly positive relevant to the level of TNF-α, but negative relevant to the activation of SOD. Conclusion: The associated detections of the activation of SOD and the content of LPO and the level of TNF-αare helpful to find out the NPC patients' immune state, and have guiding significant and value on inquiring into NPC's mechanism diagnosis, direction, Prognosis and clinical treatment.
出处
《河北医学》
CAS
2003年第3期200-203,共4页
Hebei Medicine
