摘要
目的 :了解奥氮平对器质性精神障碍的治疗作用及安全性。方法 :对 3 6例器质性精神障碍的患者用奥氮平 1.7～ 10mg·d 1 治疗 1周 ,按用药前后的兴奋因子 (BPRS)、临床总体印象量表 (CGI SI)、睡眠时间、心电图、肝肾功能进行自身t检验。结果 :除 1例脑炎患者无效外 ,兴奋因子 (BPRS)、CGI SI测评的一同减分率 >75 % 1例、5 0 %～ 75 % 16例、2 5 %～ 18例 ,显效率 47.2 % ,总有效率 97.2 %。CGI SI、睡眠时间、医疗保健评分前后比较差异有极显著性 (P <0 .0 1)、BPRS(兴奋因子 )减分率≥ 40 % ,而不良反应量表 (TESS)、心电图、肝肾功能治疗前、后差异无显著性 (P >0 .0 5 )。结论 :奥氮平对器质性精神障碍的治疗有效 ,且安全性较高。
Objective:To comprehend the effect and safety of olanzapine in treating organic mental disorder. Method:Thirty six patients of organic mental disorder were treated by olanzapine for a week. excitation factor(BPRS)?clinical global impression(CGI SI), duration of sleeping, ECG?liver/renal function before and after administration of the drug were analyzed by self T test. Results:Except that 1 case with encephalitis was inefficient, BPRS and CGI SI scores of 1 case were decreased by more than 75%, 15 cases were between 50% and 74%, 19 cases were between 25% to 49%, the efficiency was 47.2%,total efficiency was 97.2%?There were significant differences in CGI SI, duration of sleeping and medical care scores before and after therapy( P <0.01), BPRS scores were decreased by more than 40%, but there were no significant differences in TESS, ECG and liver/renal function( P >0.05). Conclusion:Olanzapine is effective and safe in treating organic mental disorder.
出处
《医药导报》
CAS
2003年第5期315-316,共2页
Herald of Medicine
关键词
奥氮平
精神障碍
器质性
Olanzapine
Mental disorder, organic
