摘要
目的探讨包合技术对中药制剂体外溶出度以及缓释作用的影响。方法选用饱和溶液法生成包合物 ,用DSC证明包合物的生成 ;采用分光光度法 ,考察盐酸小檗碱包合物的体外溶出度和缓释作用。结果 β CD·BH、RM β CD·BH和BH的T50 、Td分别为 5 69.8,740 .2min ;73 .7,10 7.0min和 19.6,2 5 .5min ,包合物的释药数据与t作线性回归方程为 :Y =0 .0 63 9t -0 .473 8,Y =0 .5 5 64t+5 .65 8。结论RM β CD·BH和 β CD·BH的溶出速率明显慢于BH ,具有一定的缓释作用 ,同时RM β CD·BH较β CD·BH具有更好的生物利用度 ;β CD·BH和β CD·BH的体外溶出度与t为一相关性良好的线性方程 ,符合零级释药方程。
Berberine hydrochloride cyclodextrin inclusion compound were prepared from saturated solution and proved by DSC. Their dissolution rate in vitro was measured by UV spectrophotometer. Results showed dissolution parameters T 50 and T d of β CD·BH, RM β CD·BH and BH were 569.8, 73.7;19.6,min;740.2?min;107.0 and 25.5 min respectively. The regression equation were Y=0.0639t- 0.4738 andY=0.5564t+ 5.658 for RM β CD·BH and β CD·BH. Their dissolution rates were quicker than that of BH, and the relation with time were linear equation.
出处
《云南化工》
CAS
2003年第2期1-3,共3页
Yunnan Chemical Technology
基金
云南省教育厅青年基金资助项目 ( 2 0 0 14 2 0 42 )
云南省教育厅面上基金资助项目 ( 0 2ZY169)
