摘要
采用计算流体动力学方法,数值求解了T型分叉流动的定常/脉动流场和低密度脂蛋白(LDL)以及血清白蛋白(Albumin)的浓度分布· 计算了雷诺数、主管和支管的流量比等参数对流场和大分子传质的影响,计算结果表明,流体动力学因素影响大分子的分布和跨壁渗透,在动脉硬化的发生和发展过程中起着重要的作用· 在流动发生分离处,即支管入口外侧壁面剪应力变化最剧烈,这儿LDL和Albumin的壁面浓度变化也是最剧烈。
A numerical analysis of the steady and pulsatile,macromolecular(such as low density lipopotein (LDL),Albumin) transport in T_bifurcation was proposed.The influence of Reynolds number and mass flow ratio etc parameters on the velocity field and mass transport were calculated.The computational results predict that the blood flow factors affect the macromolecular distribution and the transport across the wall ,it shows that hemodynamic paly an important role in the process of atherosclerosis. The LDL and Albumin concentration on the wall varies most greatly in flow bifurcation area where the wall shear stress varies greatly at the branching vessel and the atherosclerosis often appears there.
出处
《应用数学和力学》
EI
CSCD
北大核心
2003年第5期471-483,共13页
Applied Mathematics and Mechanics
基金
国家自然科学重点基金资助项目(10002003)
关键词
T型分叉
血管定常流
血管非定常流
大分子传质
T_bifurcation
steady blood flow
pulsatile blood flow
macromolecular transport
