5Schlesinger J.Cell signaling by receptor tyrosine kinases[J].Cell,2000,103,211-225.
6Hubbard R D,Bamaung N Y,Fidanze S D,et al.Development of multitargeted inhibitors of both the insulin-like growth factor receptor (IGF-IR) and members of the epidermal growth factor family of receptor tyrosine kinases[J].Bioorg.Med.Chem.Lett.2009,19,1718-1721.
7Rheault T R,Caferro T R,Dickerson S H,et al.Thienopyrimidine-based dual EGFR/ErbB-2 inhibitors[J].Bioorg.Med.Chem.Lett.,2009,19,817-820.
8Frampton J E,Easthope S E.Gefitinib[J].Drugs,2004,64(21):2475-2492.
9Gibson K H.Preparation of haloanilinoquinazolines as Class I receptor tyrosine kinase inhibitors:WO,9633980[P].1996-10-31.
10Li M D,Zheng Y G,Ji M.Synthesis of Gefitinib from Methyl 3-Hydroxy-4-methoxy-benzoate[J].Molecules,2007,12,673-678.