摘要
阿尔茨海默病(Alzheimer’s disease,AD)的早期诊断仍是临床一大难题。大量研究表明放射性核素脑显像,特别是PET显像是一种极有前途的早期诊断方法。研究显示AD早期大脑顶颞叶局部脑血流和葡萄糖代谢减低。一项研究显示PET显像可较临床诊断包括脑电图和形态学影像技术等早2年半诊断AD,其准确性超过90％。最新研究瞄准了AD的病理学特征——神经元纤维缠结和老年斑的“活体病理学”诊断,一些研究者用18F—FDDNP PET显像来定位和定量AD患者脑内的神经元纤维缠结和老年斑,监测神经元纤维缠结和老年斑有助于AD的确诊及疗效判断。
Diagnosis of early Alzheimer's disease (AD) is still a clinical challenge,growing evidence indicated radionu-elide neuroimaging, especially positron emission computed tomography (PET), would be promising for the diagnosis of early AD. Studies showed reduction of cerebral blood flow and glucose metabolism occurring at the parietotemporal lobes of AD patients at the early stage. A study showed that PET detected AD with an accuracy greater than 90% 2. 5 years earlier than clinical diagnostic methods using electroencephalography, structural imaging studies and so on. Recent investigation aimed at senile plaques (SPs) and neurofibrillary tangles (NFTs) that were hallmark pathologies accompanying the neurodegeneration involved in AD. Some researchers used 2-(l-(6-[(2-18F]fluoroethyl) (methyl)amino]-2-naphthyl)ethylidene) malononitrile (C18F]FDDNP) , in conjunction with PET to determine the localization and load of NFTs and SPs in the brains of living AD patients. Monitoring SPs and NFTs development is expected to facilitate diagnostic of AD patients and assist in response-monitoring during experimental treatments.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
2003年第4期447-450,共4页
Academic Journal of Second Military Medical University
