摘要
目的 观察IgA肾病患者外周血粘附分子CD44 (细胞表面糖蛋白 )和CD6 2P (P选择素 )表达水平的变化 ,并探讨CD44和CD6 2P在IgA肾病发病中的作用及临床意义。方法 采用流式细胞术 ,对 40例IgA肾病患者外周血CD44和CD6 2P表达进行研究 ,以 36例正常人作为对照。结果 IgA肾病患者外周血CD44、CD6 2P的表达分别为 33.89%± 13.2 9%、8.5 8%± 5 .17%明显高于正常对照组 19.73 %± 6 .82 %、3.2 6 %± 1.76 % ,差异有显著性 (P <0 .0 1) ;其中在IgA肾病Ⅳ级和Ⅴ级患者CD44、CD6 2P的表达水平亦明显高于Ⅱ级和Ⅲ级 ;相关性检验结果显示 :IgA肾病患者外周血CD44表达水平与CD6 2P的表达水平呈显著正相关 (r=0 .39,P <0 .0 5 )。结论 CD44和CD6 2P在IgA肾病患者外周血表达增强 ,在IgA肾病的发病机制中起重要作用 ,可能参与了IgA肾病的病理发展过程。
Objective To observe the changes of adhesion molecule glycoprotein (CD44) and adhesion molecule P-selectin (CD62P) expression in peripheral blood of patients with IgA nephropathy, and to explore the role and clinical significance of CD44 and CD62P in IgA nephropathy. Methods Peripheral blood samples collected from 40 IgA nephropathy patients and 36 normal people were tested for the number of lymphocytes expressing CD44 and the number of platelets expressing CD62P were counted by flow cytometry. Results The percentage of CD44-positive lymphocytes and the percentage of CD62P-positive platelets in patients with IgA nephropathy (CD44: 33.89%±13.29%; CD62P: 8.58%±5.17%) were significantly higher than those in healthy people (CD44: 19.73%±6.82%, P <0.01; CD62P: 3.26%±1.76%, P <0.01). The number of lymphocytes expressing CD44 and the number of platelets expressing CD62P in class Ⅳ and Ⅴ of IgA nephropathy were also more than in those expressing class Ⅱ and Ⅲ. Correlation analysis showed a linear correlation between CD44 and CD62P ( r =0.39, P <0.05). Conclusion The levels of expressions of CD44 and CD62P in patients with IgA nephropathy are enhanced. Our results suggest that both CD44 and CD62P play an important role in pathogenesis of IgA nephropathy, and potentially participate in the progress of IgA nephropathy. [
出处
《中华微生物学和免疫学杂志》
CAS
CSCD
北大核心
2003年第3期210-212,共3页
Chinese Journal of Microbiology and Immunology
